ArticleNature communications2011
A segmental genomic duplication generates a functional intron.
Article in Nature communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Direct repeats found in the vicinity of intron splice sites.Die Naturwissenschaften · 2025Article
- Genome-Wide Identification, Characterisation, and Evolution of the Transcription Factor WRKY in Grapevine (International journal of molecular sciences · 2024Article
- Analysis of Fungal Genomes Reveals Commonalities of Intron Gain or Loss and Functions in Intron-Poor Species.Molecular biology and evolution · 2021Article
- Internally Symmetrical Stwintrons and Related Canonical Introns in Hypoxylaceae Species.Journal of fungi (Basel, Switzerland) · 2021Article
- Article
- Next-generation sequencing of duplication CNVs reveals that most are tandem and some create fusion genes at breakpoints.American journal of human genetics · 2015Article
- At the origin of spliceosomal introns: Is multiplication of introner-like elements the main mechanism of intron gain in fungi?Communicative & integrative biology · 2013Article
- Synonymous codon usage bias is correlative to intron number and shows disequilibrium among exons in plants.BMC genomics · 2013Article
- Identifying the mechanisms of intron gain: progress and trends.Biology direct · 2012Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
An intron is an extended genomic feature whose function requires multiple constrained positions-donor and acceptor splice sites, a branch point, a polypyrimidine tract and suitable splicing enhancers-that may be distributed over hundreds or thousands of nucleotides. New introns are therefore unlikely to emerge by incremental accumulation of functional sub-elements. Here we demonstrate that a functional intron can be created de novo in a single step by a segmental genomic duplication. This experiment recapitulates in vivo the birth of an intron that arose in the ancestral jawed vertebrate lineage nearly half-a-billion years ago.
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Registered trials
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