ArticleMolecular biology and evolution2012
Species-specific features of DARC, the primate receptor for Plasmodium vivax and Plasmodium knowlesi.
Article in Molecular biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
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- Ecological complexity of zoonotic malaria in macaque natural hosts.Scientific reports · 2025Article
- Children with Plasmodium vivax infection previously observed in Namibia, were Duffy negative and carried a c.136G > A mutation.BMC infectious diseases · 2021Article
- Evolution of Hepatitis B Virus Receptor NTCP Reveals Differential Pathogenicities and Species Specificities of Hepadnaviruses in Primates, Rodents, and Bats.Journal of virology · 2019Article
- Genetic conflicts with Plasmodium parasites and functional constraints shape the evolution of erythrocyte cytoskeletal proteins.Scientific reports · 2018Article
- Molecular interactions governing host-specificity of blood stage malaria parasites.Current opinion in microbiology · 2017Review
- XRN1 Is a Species-Specific Virus Restriction Factor in Yeasts.PLoS pathogens · 2016Article
- Invasion characteristics of a Plasmodium knowlesi line newly isolated from a human.Scientific reports · 2016Article
- The role of the human Duffy antigen receptor for chemokines in malaria susceptibility: current opinions and future treatment prospects.Journal of receptor, ligand and channel research · 2016Article
- Article
- Extensive Admixture and Selective Pressure Across the Sahel Belt.Genome biology and evolution · 2015Article
- The effect of species representation on the detection of positive selection in primate gene data sets.Molecular biology and evolution · 2015Article
- Distinct genetic difference between the Duffy binding protein (PkDBPαII) of Plasmodium knowlesi clinical isolates from North Borneo and Peninsular Malaysia.Malaria journal · 2015Article
- Article
- Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.PLoS pathogens · 2014Article
- Red blood cell invasion by Plasmodium vivax: structural basis for DBP engagement of DARC.PLoS pathogens · 2014Article
- Recent host-shifts in ranaviruses: signatures of positive selection in the viral genome.The Journal of general virology · 2013Article
- Red blood cell polymorphism and susceptibility to Plasmodium vivax.Advances in parasitology · 2013Review
- Dual host-virus arms races shape an essential housekeeping protein.PLoS biology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The DARC (Duffy antigen/receptor for chemokines) gene, also called Duffy or FY, encodes a membrane-bound chemokine receptor. Two malaria parasites, Plasmodium vivax and Plasmodium knowlesi, use DARC to trigger internalization into red blood cells. Although much has been reported on the evolution of DARC null alleles, little is known about the evolution of the coding portion of this gene or the role that protein sequence divergence in this receptor may play in disease susceptibility or zoonosis. Here, we show that the Plasmodium interaction domain of DARC is nearly invariant in the human population, suggesting that coding polymorphism there is unlikely to play a role in differential susceptibility to infection. However, an analysis of DARC orthologs from 35 simian primate species reveals high levels of sequence divergence in the Plasmodium interaction domain. Signatures of positive selection in this domain indicate that species-specific mutations in the protein sequence of DARC could serve as barriers to the transmission of Plasmodium between primate species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.