ArticlePhysiological genomics2011
Homogenous protein programming in the mammalian left and right ventricle free walls.
Article in Physiological genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
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- Differential mitochondrial bioenergetics and cellular resilience in astrocytes, hepatocytes, and fibroblasts from aging baboons.bioRxiv : the preprint server for biology · 2024Article
- Cardiac nitric oxide scavenging: role of myoglobin and mitochondria.The Journal of physiology · 2024Article
- Mitochondrial Integrity Is Critical in Right Heart Failure Development.International journal of molecular sciences · 2023Review
- Right Heart Failure in Mice Upon Pressure Overload Is Promoted by Mitochondrial Oxidative Stress.JACC. Basic to translational science · 2022Article
- Lower troponin expression in the right ventricle of rats explains interventricular differences in E-C coupling.The Journal of general physiology · 2022Article
- Right ventricular phenotype, function, and failure: a journey from evolution to clinics.Heart failure reviews · 2021Review
- Cardioprotection in right heart failure.British journal of pharmacology · 2020Review
- FHL-1 is not involved in pressure overload-induced maladaptive right ventricular remodeling and dysfunction.Basic research in cardiology · 2020Article
- Perfused murine heart optical transmission spectroscopy using optical catheter and integrating sphere: Effects of ischemia/reperfusion.Analytical biochemistry · 2019Article
- EXPRESS: Right Heart in Pulmonary Hypertension: From Adaptation to Failure.Pulmonary circulation · 2019Article
- Proteomic analysis of cardiac ventricles: baso-apical differences.Molecular and cellular biochemistry · 2018Article
- Review on Chamber-Specific Differences in Right and Left Heart Reactive Oxygen Species Handling.Frontiers in physiology · 2018Article
- Intracardiac light catheter for rapid scanning transmural absorbance spectroscopy of perfused myocardium: measurement of myoglobin oxygenation and mitochondria redox state.American journal of physiology. Heart and circulatory physiology · 2017Article
- Molecular Mechanisms of Right Ventricular Failure.Circulation · 2015Review
- Right ventricular protein expression profile in end-stage heart failure.Pulmonary circulation · 2015Article
- Interventricular differences in β-adrenergic responses in the canine heart: role of phosphodiesterases.Journal of the American Heart Association · 2014Article
- Pressure-overload hypertrophy of the developing heart reveals activation of divergent gene and protein pathways in the left and right ventricular myocardium.American journal of physiology. Heart and circulatory physiology · 2013Article
- Allometry of brain metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Perspectives on: SGP symposium on mitochondrial physiology and medicine: metabolic homeostasis of the heart.The Journal of general physiology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Despite identical cardiac outputs, the right (RV) and left ventricle (LV) have very different embryological origins and resting workload. These differences suggest that the ventricles have different protein programming with regard to energy metabolism and contractile elements. The objective of this study was to determine the relative RV and LV protein expression levels, with an emphasis on energy metabolism. The RV and LV protein contents of the rabbit and porcine heart were determined with quantitative gel electrophoresis (2D-DIGE), mass spectrometry, and optical spectroscopy techniques. Surprisingly, the expression levels for more than 600 RV and LV proteins detected were similar. This included proteins many different compartments and metabolic pathways. In addition, no isoelectric shifts were detected in 2D-DIGE consistent with no differential posttranslational modifications in these proteins. Analysis of the RV and LV metabolic response to work revealed that the metabolic rate increases much faster with workload in the RV compared with LV. This implies that the generally lower metabolic stress of the RV actually approaches LV metabolic stress at maximum workloads. Thus, identical levels of energy conversion and mechanical elements in the RV and LV may be driven by the performance requirements at maximum workloads. In summary, the ventricles of the heart manage the differences in overall workload by modifying the amounts of cytosol, not its composition. The constant myocyte composition in the LV and RV implies that the ratio of energy metabolism and contractile elements may be optimal for the sustained cardiac contractile activity in the mammalian heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.