Evidence map›Paper›PMID 21878520›Full record

Trial reportThe Journal of physiology2011

Implications of group III and IV muscle afferents for high-intensity endurance exercise performance in humans.

Markus Amann, Gregory M Blain, Lester T Proctor, Joshua J Sebranek, David F Pegelow, Jerome A Dempsey

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  9. Effects of surgical and FFP2/N95 face masks on cardiopulmonary exercise capacity.Clinical research in cardiology : official journal of the German Cardiac Society · 2020
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80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Markus AmannUniversity of Utah, Department of Internal Medicine, Salt Lake City, UT, USA. markus.amann@hsc.utah.edu
Gregory M Blain
Lester T Proctor
Joshua J Sebranek
David F Pegelow
Jerome A Dempsey

Funding

HUMAN VENTILATORY ADAPTIONR01HL015469 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI DEMPSEY, JEROME A · 1985 to 2011
$3.7M
Work of Breathing and Oxidative Stress in COPD: Impact on Blood Flow and FatigueR00HL103786 · NHLBI · UNIVERSITY OF UTAH · PI AMANN, MARKUS · 2013 to 2015
$738k
Respiratory muscle work and oxidative stress in COPD: impact on leg blood flow anK99HL103786 · NHLBI · UNIVERSITY OF UTAH · PI AMANN, MARKUS · 2010 to 2011
$161k
HUMAN VENTILLATORY ADAPTATIONR37HL015469 · NHLBI · UNIVERSITY OF WISCONSIN MADISON · PI DEMPSEY, JEROME A · 1988 to 1996
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NHLBI NIH HHS HL-103786-02NHLBI NIH HHS HL-15469NHLBI NIH HHS K99 HL103786NHLBI NIH HHS R00 HL103786NHLBI NIH HHS R01 HL015469
6 · The paper itself

Abstract

We investigated the influence of group III/IV muscle afferents on peripheral fatigue, central motor drive (CMD) and endurance capacity during high-intensity leg-cycling. In a double-blind, placebo-controlled design, seven males performed constant-load cycling exercise (318 ± 9 W; 80% of peak power output (W(peak))) to exhaustion under placebo conditions and with lumbar intrathecal fentanyl impairing spinal μ-opioid receptor-sensitive group III/IV muscle afferents. Peripheral fatigue was assessed via changes in pre- vs. post-exercise quadriceps force in response to supramaximal magnetic femoral nerve stimulation (ΔQ(tw,pot)). CMD was estimated via quadriceps electromyogram. To rule out a direct central effect of fentanyl, we documented unchanged resting cardioventilatory responses. Compared to placebo, significant hypoventilation during the fentanyl trial was indicated by the 9% lower V(E)/V(CO(2)), causing a 5 mmHg increase in end-tidal P(CO(2)) and a 3% lower haemoglobin saturation. Arterial pressure and heart rate averaged 8 and 10% lower, respectively, during the fentanyl trial and these differences progressively diminished towards end-exercise. Although initially similar, the percent change in CMD was 9 ± 3% higher at end-exercise with fentanyl vs. placebo (P < 0.05). Time to exhaustion was shorter (6.8 ± 0.3 min vs. 8.7 ± 0.3 min) and end-exercise ΔQ(tw,pot) was about one-third greater (-44 ± 2% vs. -34 ± 2%) following fentanyl vs. placebo. The rate of peripheral fatigue development was 67 ± 10% greater during the fentanyl trial (P < 0.01). Our findings suggest that feedback from group III/IV muscle afferents limits CMD but also minimizes locomotor muscle fatigue development by stimulating adequate ventilatory and circulatory responses to exercise. In the face of blocked group III/IV muscle afferents, CMD is less inhibited but O(2) transport compromised and locomotor muscle fatigability is exacerbated with a combined net effect of a reduced endurance performance.

Indexed as

AdultAnalgesics, OpioidElectromyographyExerciseFentanylHeart RateHumansMagnetic Field TherapyMaleMuscle FatigueMuscle Fibers, SkeletalPhysical EndurancePulmonary VentilationQuadriceps MuscleYoung AdultAnalgesics, OpioidFentanyl

Identifiers

PMID21878520
PMCPMC3225681

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.