ArticleJournal of cell science2011
Protein phosphatase 5 is a negative regulator of separase function during cortical granule exocytosis in C. elegans.
Article in Journal of cell science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Anaphase onset requires CKS-1-mediated destruction of securin in meiosis I and cyclin B1 in meiosis II.The Journal of cell biology · 2026Article
- Securin regulates the spatiotemporal dynamics of separase.The Journal of cell biology · 2025Article
- The embryonic lethal mutationmicroPublication biology · 2025Article
- Securin Regulates the Spatiotemporal Dynamics of Separase.bioRxiv : the preprint server for biology · 2023Article
- Functional analysis of a novel de novo variant in PPP5C associated with microcephaly, seizures, and developmental delay.Molecular genetics and metabolism · 2022Article
- Structure and Function of the Separase-Securin Complex.Sub-cellular biochemistry · 2021Review
- Opposing effects of an F-box protein and the HSP90 chaperone network on microtubule stability and neurite growth inDevelopment (Cambridge, England) · 2020Article
- Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death.Scientific reports · 2020Article
- Structural biology of the separase-securin complex with crucial roles in chromosome segregation.Current opinion in structural biology · 2018Review
- Genetic Identification of Separase Regulators inG3 (Bethesda, Md.) · 2018Article
- Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.Journal of cancer science & therapy · 2018Article
- The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes.Frontiers in pharmacology · 2018Article
- From phenologs to silent suppressors: Identifying potential therapeutic targets for human disease.Molecular reproduction and development · 2017Review
- Protease dead separase inhibits chromosome segregation and RAB-11 vesicle trafficking.Cell cycle (Georgetown, Tex.) · 2017Article
- C. elegans as a model for membrane traffic.WormBook : the online review of C. elegans biology · 2014Review
- Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Mutations in the Caenorhabditis elegans separase gene, sep-1, are embryonic lethal. Newly fertilized mutant embryos have defects in polar body extrusion, fail to undergo cortical granule exocytosis, and subsequently fail to complete cytokinesis. Chromosome nondisjunction during the meiotic divisions is readily apparent after depletion of sep-1 by RNAi treatment, but much less so in hypomorphic mutant embryos. To identify factors that influence the activity of separase in cortical granule exocytosis and cytokinesis, we carried out a genetic suppressor screen. A mutation in the protein phosphatase 5 (pph-5) gene was identified as an extragenic suppressor of sep-1. This mutation suppressed the phenotypes of hypomorphic separase mutants but not RNAi depleted animals. Depletion of pph-5 caused no phenotypes on its own, but was effective in restoring localization of mutant separase to vesicles and suppressing cortical granule exocytosis and cytokinesis phenotypes. The identification of PPH-5 as a suppressor of separase suggests that a new phospho-regulatory pathway plays an important role in regulating anaphase functions of separase.
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Registered trials
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