ArticleJournal of cell science2011
Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands.
Article in Journal of cell science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 60 citations in OpenAlex.
- Defective targeting of PNPLA1 to lipid droplets causes ichthyosis in ABHD5-syndromic epidermal differentiation disorder.Journal of lipid research · 2025Article
- ACSL3 regulates breast cancer progressionCancer biology & medicine · 2024Article
- Comparative proteomic analysis of human milk fat globules and paired membranes and mouse milk fat globules identifies core cellular systems contributing to mammary lipid trafficking and secretion.Frontiers in molecular biosciences · 2023Article
- Review
- Perilipin-2 limits remyelination by preventing lipid droplet degradation.Cellular and molecular life sciences : CMLS · 2022Article
- Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR.PLoS biology · 2022Article
- Perilipin-2 promotes lipid droplet-plasma membrane interactions that facilitate apocrine lipid secretion in secretory epithelial cells of the mouse mammary gland.Frontiers in cell and developmental biology · 2022Article
- Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland.Frontiers in cell and developmental biology · 2021Article
- Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing.Cell reports · 2020Article
- Pistacia lentiscus extract enhances mammary epithelial cells' productivity by modulating their oxidative status.Scientific reports · 2020Article
- RAB6 GTPase regulates mammary secretory function by controlling the activation of STAT5.Development (Cambridge, England) · 2020Article
- Progesterone Regulation of Milk Fat Globule Size Is VLDL Dependent.Frontiers in endocrinology · 2020Article
- Effects of Dietary Vegetable Oils on Mammary Lipid-Related Genes in Holstein Dairy Cows.Animals : an open access journal from MDPI · 2019Article
- Electron Tomography Revels that Milk Lipids Originate from Endoplasmic Reticulum Domains with Novel Structural Features.Journal of mammary gland biology and neoplasia · 2019Article
- Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation.Nature communications · 2018Article
- Milk lipid regulation at the maternal-offspring interface.Seminars in cell & developmental biology · 2018Review
- Moderate High Temperature Condition Induces the Lactation Capacity of Mammary Epithelial Cells Through Control of STAT3 and STAT5 Signaling.Journal of mammary gland biology and neoplasia · 2018Article
- Lipid Droplet Fusion in Mammary Epithelial Cells is Regulated by Phosphatidylethanolamine Metabolism.Journal of mammary gland biology and neoplasia · 2017Article
- The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017Review
- CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Milk lipids originate by secretion of triglyceride-rich cytoplasmic lipid droplets (CLDs) from mammary epithelial cells. Adipophilin (ADPH)/Plin2, a member of the perilipin family of CLD binding proteins, is hypothesized to regulate CLD production in these cells during differentiation of the mammary gland into a secretory organ. We tested this hypothesis by comparing CLD accumulation in differentiating mammary glands of wild-type and ADPH-deficient mice. ADPH deficiency did not prevent CLD formation; however, it disrupted the increase in CLD size that normally occurs in differentiating mammary epithelial cells. Failure to form large CLDs in ADPH-deficient mice correlated with localization of adipose triglyceride lipase (ATGL) to the CLD surface, suggesting that ADPH promotes CLD growth by inhibiting lipolytic activity. Significantly, mammary alveoli also failed to mature in ADPH-deficient mice, and pups born to these mice failed to survive. The possibility that CLD accumulation and alveolar maturation defects in ADPH-deficient mice are functionally related was tested by in vivo rescue experiments. Transduction of mammary glands of pregnant ADPH-deficient mice with adenovirus encoding ADPH as an N-terminal GFP fusion protein prevented ATGL from localizing to CLDs and rescued CLD size and alveolar maturation defects. Collectively, these data provide direct in vivo evidence that ADPH inhibition of ATGL-dependent lipolysis is required for normal CLD accumulation and alveolar maturation during mammary gland differentiation. We speculate that impairing CLD accumulation interferes with alveolar maturation and lactation by disrupting triglyceride homeostasis in mammary epithelial cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.