ArticleBMC genetics2011
The impact of modern migrations on present-day multi-ethnic Argentina as recorded on the mitochondrial DNA genome.
Article in BMC genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 69 citations in OpenAlex.
- Genetic ancestry of families of putative Inka descent.Molecular genetics and genomics : MGG · 2018Trial
- Integrating genetic, historical, and demographic evidence to reconstruct Argentina's matrilineal ancestry.Human genetics · 2026Article
- The Ancestry of Eastern Paraguay: A Typical South American Profile with a Unique Pattern of Admixture.Genes · 2021Article
- Mitochondrial Polymorphisms, in The D-Loop Area, Are Associated with Brain Tumors.Cell journal · 2019Article
- Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications.Journal of assisted reproduction and genetics · 2018Article
- Genetic variation in populations from central Argentina based on mitochondrial and Y chromosome DNA evidence.Journal of human genetics · 2018Article
- Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina.PloS one · 2018Article
- Complex spatio-temporal distribution and genomic ancestry of mitochondrial DNA haplogroups in 24,216 Danes.PloS one · 2018Article
- The -2518 A/G polymorphism in the monocyte chemoattractant protein 1 gene (MCP-1) is associated with an increased risk of rheumatoid arthritis in Argentine patients.Clinical rheumatology · 2016Article
- Charting the Y-chromosome ancestry of present-day Argentinean Mennonites.Journal of human genetics · 2016Article
- Influence of ethnicity on the distribution of genetic polymorphisms associated with risk of chronic liver disease in South American populations.BMC genetics · 2015Article
- Genomic insights on the ethno-history of the Maya and the 'Ladinos' from Guatemala.BMC genomics · 2015Article
- Different Evolutionary History for Basque Diaspora Populations in USA and Argentina Unveiled by Mitochondrial DNA Analysis.PloS one · 2015Article
- A South American Prehistoric Mitogenome: Context, Continuity, and the Origin of Haplogroup C1d.PloS one · 2015Article
- 4G/5G plasminogen activator inhibitor-1 and -308 A/G tumor necrosis factor-α promoter gene polymorphisms in Argentinean lupus patients: focus on lupus nephritis.Clinical and experimental medicine · 2014Article
- Article
- Rapid coastal spread of First Americans: novel insights from South America's Southern Cone mitochondrial genomes.Genome research · 2012Article
- The Basque paradigm: genetic evidence of a maternal continuity in the Franco-Cantabrian region since pre-Neolithic times.American journal of human genetics · 2012Article
- Human leukocyte antigen profiles of latin american populations: differential admixture and its potential impact on hematopoietic stem cell transplantation.Bone marrow research · 2012Article
- Arrival of Paleo-Indians to the southern cone of South America: new clues from mitogenomes.PloS one · 2012Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe genetic background of Argentineans is a mosaic of different continental ancestries. From colonial to present times, the genetic contribution of Europeans and sub-Saharan Africans has superposed to or replaced the indigenous genetic 'stratum'. A sample of 384 individuals representing different Argentinean provinces was collected and genotyped for the first and the second mitochondrial DNA (mtDNA) hypervariable regions, and selectively genotyped for mtDNA SNPs. This data was analyzed together with additional 440 profiles from rural and urban populations plus 304 from Native American Argentineans, all available from the literature. A worldwide database was used for phylogeographic inferences, inter-population comparisons, and admixture analysis. Samples identified as belonging to hg (hg) H2a5 were sequenced for the entire mtDNA genome.
resultsPhylogenetic and admixture analyses indicate that only half of the Native American component in urban Argentineans might be attributed to the legacy of extinct ancestral Argentineans and that the Spanish genetic contribution is slightly higher than the Italian one. Entire H2a5 genomes linked these Argentinean mtDNAs to the Basque Country and improved the phylogeny of this Basque autochthonous clade. The fingerprint of African slaves in urban Argentinean mtDNAs was low and it can be phylogeographically attributed predominantly to western African. The European component is significantly more prevalent in the Buenos Aires province, the main gate of entrance for Atlantic immigration to Argentina, while the Native American component is larger in North and South Argentina. AMOVA, Principal Component Analysis and hgs/haplotype patterns in Argentina revealed an important level of genetic sub-structure in the country.
conclusionsStudies aimed to compare mtDNA frequency profiles from different Argentinean geographical regions (e.g., forensic and case-control studies) should take into account the important genetic heterogeneity of the country in order to prevent false positive claims of association in disease studies or inadequate evaluation of forensic evidence.
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