Evidence map›Paper›PMID 21877259›Full record

ReviewCurrent topics in behavioral neurosciences2013

Signaling pathways mediating alcohol effects.

Dorit Ron, Robert O Messing

Abstract readReview
In one paragraph

Review in Current topics in behavioral neurosciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
27.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
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  10. Acetaldehyde Excitation of Lateral Habenular Neurons via Multiple Cellular Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
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  13. Review
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  19. Article
  20. Protein kinase C: perfectly balanced.Critical reviews in biochemistry and molecular biology · 2018
    Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Dorit RonErnest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA. dron@gallo.ucsf.edu
Robert O Messing
Ernest Gallo Clinic and Research Center · US

Funding

Vector, Transgenic, and Imaging CoreP50AA017072 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RON, DORIT · 2008 to 2017
$13.9M
Phosphorylation and the CNS Actions of EthanolR01AA013438 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RON, DORIT · 2002 to 2012
$3.7M
Regulation of GABAA Receptors by PKC epsilon.R37AA013588 · NIAAA · ERNEST GALLO CLINIC AND RESEARCH CENTER · PI MESSING, ROBERT O. · 2003 to 2011
$3.7M
BDNF and Alcohol AddictionR37AA016848 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RON, DORIT · 2013 to 2022
$3.7M
The Neurotrophic Factor GDNF and Alcohol AddictionR01AA014366 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RON, DORIT · 2004 to 2013
$3.3M
Regulation of GABAA Receptors by PKC epsilon.R01AA013588 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI MESSING, ROBERT O. · 2002 to 2016
$1.9M
BDNF and Alcohol AddictionR01AA016848 · NIAAA · ERNEST GALLO CLINIC AND RESEARCH CENTER · PI RON, DORIT · 2008 to 2012
$1.8M
PKC Delta in Ethanol Regulation of GABA-A Receptors and BehaviorR01AA018316 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI MESSING, ROBERT O. · 2009 to 2013
$1.7M
NIAAA NIH HHS AA013438NIAAA NIH HHS AA013588NIAAA NIH HHS AA014366NIAAA NIH HHS AA016848NIAAA NIH HHS AA017072NIAAA NIH HHS AA018316NIAAA NIH HHS P50 AA017072NIAAA NIH HHS R01 AA013438NIAAA NIH HHS R01 AA013588NIAAA NIH HHS R01 AA014366NIAAA NIH HHS R01 AA016848NIAAA NIH HHS R01 AA018316NIAAA NIH HHS R37 AA013588NIAAA NIH HHS R37 AA016848
6 · The paper itself

Abstract

Ethanol's effects on intracellular signaling pathways contribute to acute effects of ethanol as well as to neuroadaptive responses to repeated ethanol exposure. In this chapter we review recent discoveries that demonstrate how ethanol alters signaling pathways involving several receptor tyrosine kinases and intracellular tyrosine and serine-threonine kinases, with consequences for regulation of cell surface receptor function, gene expression, protein translation, neuronal excitability and animal behavior. We also describe recent work that demonstrates a key role for ethanol in regulating the function of scaffolding proteins that organize signaling complexes into functional units. Finally, we review recent exciting studies demonstrating ethanol modulation of DNA and histone modification and the expression of microRNAs, indicating epigenetic mechanisms by which ethanol regulates neuronal gene expression and addictive behaviors.

Indexed as

AnimalsCentral Nervous System DepressantsEthanolProtein Serine-Threonine KinasesReceptor Protein-Tyrosine KinasesSignal TransductionCentral Nervous System DepressantsEthanolProtein Serine-Threonine KinasesReceptor Protein-Tyrosine Kinases

Identifiers

PMID21877259
PMCPMC3684072
OpenAlexW1517470090

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.