SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2011
Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.
Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Pooled it
- Bioinformatics analysis of genetic variants of endoplasmic reticulum aminopeptidase 1 in ankylosing spondylitis.Molecular medicine reports · 2017Pooled it
- MEFV M694V mutation has a role in susceptibility to ankylosing spondylitis: A meta-analysis.PloS one · 2017Pooled it
- Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis.Clinical rheumatology · 2016Pooled it
- Anti-protein phosphatase magnesium-dependent 1A-IgM levels in patients with active ankylosing spondylitis: a potential biomarker.Advances in rheumatology (London, England) · 2024Article
- Review
- Evaluation of the early cervical structural change in patients with non-radiographic axial spondyloarthropathy.Rheumatology international · 2022Observational
- Research hotspots and trends analysis of ankylosing spondylitis: a bibliometric and scientometric analysis from 2009 to 2018.Annals of translational medicine · 2020Article
- A Mechanism Underlying Sex-Associated Differences in Ankylosing Spondylitis: Troponin C2, Fast Skeletal Type (TNNC2) and Calcium Signaling Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Epistatic interaction of ERAP1 and HLA-B in Behçet disease: a replication study in the Spanish population.PloS one · 2014Article
- Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.Autoimmunity · 2013Article
- Ankylosing spondylitis: from cells to genes.International journal of inflammation · 2013Article
- Endoplasmic reticulum aminopeptidase 1 and interleukin-23 receptor in ankylosing spondylitis.Current rheumatology reports · 2012Review
- Significant association between insertion/deletion polymorphism of the angiotensin-convertig enzyme gene and ankylosing spondylitis.Molecular vision · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to determine whether five polymorphisms of endoplasmic reticulum aminopeptidase 1 (ERAP1) confer susceptibility to ankylosing spondylitis (AS).
methodsThe authors conducted five types of meta-analysis on the associations between the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 and AS susceptibility, using fixed and random effects models.
resultsSix studies were included in this meta-analysis, which in total involved 4,594 AS patients and 3,971 controls, five European populations, and one Asian population. Meta-analysis identified a significant association between AS and the two alleles of the rs27044 polymorphism in all study subjects [odds ratio (OR) = 1.333, 95% confidence interval (CI) = 1.102-1.612, p = 0.003]. Stratification by ethnicity identified a significant association between this polymorphism and AS in Europeans (OR = 1.281, 95% CI = 1.032-1.588, p = 0.024) and in Asians (OR = 1.554, 95% CI = 1.313-1.838, p = 2 × 10(-8)), and meta-analysis of the rs30187 polymorphism showed the same pattern. Furthermore, analysis revealed significant associations between the two alleles of the rs17482078, rs10050860, and rs2287987 polymorphisms and the risk of developing AS in Europeans (OR = 0.726, 95% CI = 0.655-0.805, p < 1 × 10(-10); OR = 0.724, 95% CI = 0.665-0.787, p < 1 × 10(-10); OR = 0.708, 95% CI = 0.639-0.784, p < 1 × 10(-10), respectively). However, the single Asian study included showed no association between the rs17482078, rs30187, and rs2287987 polymorphisms and AS.
conclusionsThis meta-analysis shows that the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 are associated with the development of AS in Europeans. However, further study of this association is required in other ethnic groups.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.