Evidence map›Paper›PMID 21877166›Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2011

Biokinetics and dosimetry of commonly used radiopharmaceuticals in diagnostic nuclear medicine - a review.

Uta Eberlein, Jörn Hendrik Bröer, Charlot Vandevoorde, Paula Santos, Manuel Bardiès, Klaus Bacher, Dietmar Nosske, Michael Lassmann

Abstract readReview
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. How can we optimise the pharmaceutical analysis of radiopharmaceutical pediatric prescriptions?European journal of hospital pharmacy : science and practice · 2023
    Review
  2. Review
  3. EANM position paper on the role of radiobiology in nuclear medicine.European journal of nuclear medicine and molecular imaging · 2021
    Article
  4. Species Differences in Microsomal Metabolism of Xanthine-Derived APharmaceuticals (Basel, Switzerland) · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. In vivo Exposure Effects ofAsia Oceania journal of nuclear medicine & biology · 2018
    Article
  9. Article
  10. Standardization of administered activities in paediatric nuclear medicine: the EANM perspective.European journal of nuclear medicine and molecular imaging · 2016
    Article
  11. Article
  12. Article
  13. Biodistribution and radiation dosimetry for a probe targeting prostate-specific membrane antigen for imaging and therapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015
    Article
  14. Article
  15. Article
  16. Dosimetry ofJournal of medical physics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Uta EberleinDepartment of Nuclear Medicine, University of Würzburg, Oberdürrbacher Str. 6, 97080 Würzburg, Germany. eberlein_u@klinik.uni-wuerzburg.de
Jörn Hendrik Bröer
Charlot Vandevoorde
Paula Santos
Manuel Bardiès
Klaus Bacher
Dietmar Nosske
Michael Lassmann

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe impact on patients' health of radiopharmaceuticals in nuclear medicine diagnostics has not until now been evaluated systematically in a European context. Therefore, as part of the EU-funded Project PEDDOSE.NET ( www.peddose.net ), we review and summarize the current knowledge on biokinetics and dosimetry of commonly used diagnostic radiopharmaceuticals.

methodsA detailed literature search on published biokinetic and dosimetric data was performed mostly via PubMed ( www.ncbi.nlm.nih.gov/pubmed ). In principle the criteria for inclusion of data followed the EANM Dosimetry Committee guidance document on good clinical reporting.

resultsData on dosimetry and biokinetics can be difficult to find, are scattered in various journals and, especially in paediatric nuclear medicine, are very scarce. The data collection and calculation methods vary with respect to the time-points, bladder voiding, dose assessment after the last data point and the way the effective dose was calculated. In many studies the number of subjects included for obtaining biokinetic and dosimetry data was fewer than ten, and some of the biokinetic data were acquired more than 20 years ago.

conclusionIt would be of interest to generate new data on biokinetics and dosimetry in diagnostic nuclear medicine using state-of-the-art equipment and more uniform dosimetry protocols. For easier public access to dosimetry data for diagnostic radiopharmaceuticals, a database containing these data should be created and maintained.

Indexed as

Body BurdenModels, BiologicalRadiation DosageComputer SimulationHumansMetabolic Clearance RateRadiometryRadiopharmaceuticalsRadiopharmaceuticals

Identifiers

PMID21877166
PMCPMC3218267

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.