ArticleBreast cancer research and treatment2012
Tissue composition of mammographically dense and non-dense breast tissue.
Article in Breast cancer research and treatment, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Reproductive Factors and Mammographic Density: Associations Among 24,840 Women and Comparison of Studies Using Digitized Film-Screen Mammography and Full-Field Digital Mammography.American journal of epidemiology · 2019Pooled it
- Measurement of breast density with digital breast tomosynthesis--a systematic review.The British journal of radiology · 2014Pooled it
- Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.The Journal of clinical investigation · 2020Trial
- Advancements in Developing an Automated Breast Density Detection Technique for Breast Cancer Risk Prediction: Synthesizing a Signal-dependent Noise Stochastic Process.bioRxiv : the preprint server for biology · 2026Article
- Histologic correlates of background parenchymal uptake on molecular breast imaging.Breast cancer research : BCR · 2025Observational
- Spatial localization of collagen hydroxylated proline site variation as an ancestral trait in the breast cancer microenvironment.Matrix biology : journal of the International Society for Matrix Biology · 2025Article
- Association between breastfeeding, mammographic density, and breast cancer risk: a review.International breastfeeding journal · 2024Review
- Temporal changes in mammographic breast density and breast cancer risk among women with benign breast disease.Breast cancer research : BCR · 2024Article
- Automated 3D Ultrasound as an Adjunct to Screening Mammography Programs in Dense Breast: Literature Review and Metanalysis.Journal of personalized medicine · 2023Review
- Pathological macroscopic evaluation of breast density versus mammographic breast density in breast cancer conserving surgery.European journal of obstetrics & gynecology and reproductive biology: X · 2023Article
- Breast density is strongly associated with multiparametric magnetic resonance imaging biomarkers and pro-tumorigenic proteins in situ.British journal of cancer · 2022Article
- Association of breast cancer risk, density, and stiffness: global tissue stiffness on breast MR elastography (MRE).Breast cancer research and treatment · 2022Article
- Sensing mammographic density using single-sided portable Nuclear Magnetic Resonance.Saudi journal of biological sciences · 2022Article
- Circulating proteins reveal prior use of menopausal hormonal therapy and increased risk of breast cancer.Translational oncology · 2022Article
- Breast Density and Estradiol Are Major Determinants for Soluble TNF-TNF-R ProteinsFrontiers in immunology · 2022Article
- Biological Mechanisms and Therapeutic Opportunities in Mammographic Density and Breast Cancer Risk.Cancers · 2021Review
- Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021Observational
- Comparison of sonoelastographic values of breast tissue with mammographically and ultrasonically assessed density: a cross-sectional study.Croatian medical journal · 2020Article
- Alcohol and Tobacco Use in Relation to Mammographic Density in 23,456 Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- A review of the influence of mammographic density on breast cancer clinical and pathological phenotype.Breast cancer research and treatment · 2019Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Mammographic density is a strong risk factor for breast cancer but its underlying biology in healthy women is not well-defined. Using a novel collection of core biopsies from mammographically dense versus non-dense regions of the breasts of healthy women, we examined histologic and molecular differences between these two tissue types. Eligible participants were 40 + years, had a screening mammogram and no prior breast cancer or current endocrine therapy. Mammograms were used to identify dense and non-dense regions and ultrasound-guided core biopsies were performed to obtain tissue from these regions. Quantitative assessment of epithelium, stroma, and fat was performed on dense and non-dense cores. Molecular markers including Ki-67, estrogen receptor (ER) and progesterone receptor (PR) were also assessed for participants who had >0% epithelial area in both dense and non-dense tissue. Signed rank test was used to assess within woman differences in epithelium, stroma and fat between dense and non-dense tissue. Differences in molecular markers (Ki-67, ER, and PR) were analyzed using generalized linear models, adjusting for total epithelial area. Fifty-nine women, mean age 51 years (range: 40-82), were eligible for analyses. Dense tissue was comprised of greater mean areas of epithelium and stroma (1.1 and 9.2 mm(2) more, respectively) but less fat (6.0 mm(2) less) than non-dense tissue. There were no statistically significant differences in relative expression of Ki-67 (P = 0.82), ER (P = 0.09), or PR (P = 0.96) between dense and non-dense tissue. Consistent with prior reports, we found that mammographically dense areas of the breast differ histologically from non-dense areas, reflected in greater proportions of epithelium and stroma and lesser proportions of fat in the dense compared to non-dense breast tissue. Studies of both epithelial and stromal components are important in understanding the association between mammographic density and breast cancer risk.
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