ArticleCancer causes & control : CCC2011
Regular aspirin use and breast cancer risk in US Black women.
Article in Cancer causes & control : CCC, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Integrative Bioinformatic and Epidemiological Analysis of Acetaminophen Use and Risk of Sex Hormone-Related Cancers.International journal of molecular sciences · 2025Pooled it
- Aspirin might reduce the incidence of breast cancer: An updated meta-analysis of 38 observational studies.Medicine · 2020Pooled it
- Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies.BMC cancer · 2018Pooled it
- Aspirin as a potential modality for the chemoprevention of breast cancer: A dose-response meta-analysis of cohort studies from 857,831 participants.Oncotarget · 2017Pooled it
- Low-dose acetylsalicylic acid reduces local inflammation and tissue perfusion in dense breast tissue in postmenopausal women.Breast cancer research : BCR · 2024Trial
- Differential Causal Effects of Common Analgesics on Breast Cancer Risk and Survival: Evidence from Mendelian Randomization.International journal of women's health · 2025Article
- Celecoxib inhibits NLRP1 inflammasome pathway in MDA-MB-231 Cells.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Associations of aspirin and other anti-inflammatory medications with breast cancer risk by the status of COX-2 expression.Breast cancer research : BCR · 2022Article
- Use of nonsteroidal anti-inflammatory drugs and breast cancer risk in a prospective cohort of postmenopausal women.Breast cancer research : BCR · 2020Article
- Aspirin use and risk of breast cancer in African American women.Breast cancer research : BCR · 2020Article
- Associations of aspirin and other anti-inflammatory medications with mammographic breast density and breast cancer risk.Cancer causes & control : CCC · 2020Article
- Celecoxib in breast cancer prevention and therapy.Cancer management and research · 2018Review
- Regular and low-dose aspirin, other non-steroidal anti-inflammatory medications and prospective risk of HER2-defined breast cancer: the California Teachers Study.Breast cancer research : BCR · 2017Article
- Use of acetaminophen in relation to the occurrence of cancer: a review of epidemiologic studies.Cancer causes & control : CCC · 2016Review
- The Role of NSAIDs in Breast Cancer Prevention and Relapse: Current Evidence and Future Perspectives.Breast care (Basel, Switzerland) · 2016Review
- Lifetime use of nonsteroidal anti-inflammatory drugs and breast cancer risk: results from a prospective study of women with a sister with breast cancer.BMC cancer · 2015Article
- Can Aspirin and Cancer Prevention be Ageless Companions?Journal of clinical and diagnostic research : JCDR · 2015Review
- Cyclooxygenase-2 and the inflammogenesis of breast cancer.World journal of clinical oncology · 2014Review
- Use of aspirin, other nonsteroidal anti-inflammatory drugs, and acetaminophen and postmenopausal breast cancer incidence.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEpidemiologic studies have yet to provide consistent evidence to support a protective effect of aspirin and other non-steroidal anti-inflammatory drugs (NSAID) on the incidence of breast cancer.
objectiveWe evaluated the relations of current use of aspirin, non-aspirin NSAIDs, and acetaminophen with breast cancer incidence in the Black Women's Health Study.
methodsBiennial follow-up of 59,000 study participants began in 1995. During 558,600 person-years of follow-up through 2007, 1,275 breast cancer cases were identified. Using Cox proportional hazards regression, we estimated incidence rate ratios (IRR) and 95% confidence intervals (CI) for associations of current and former use of aspirin, other NSAIDs, and acetaminophen with incident breast cancer.
resultsAfter adjustment for age, education, body mass index at age 18, physical activity, female hormone use, current smoking, and other NSAID use, the IRRs were 0.79 (95% CI = 0.66, 0.95) for current aspirin use and 0.68 (95% CI = 0.50, 0.92) for ≥5 years of aspirin use. Similar associations were observed for acetaminophen use.
conclusionsBoth aspirin and acetaminophen use were inversely associated with breast cancer incidence in the present study. Reasons for the association with acetaminophen use are unclear, given that acetaminophen has very weak anti-inflammatory effects.
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Registered trials
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