ArticlePediatric radiology2012
Fracture after bisphosphonate treatment in children with cerebral palsy: the role of stress risers.
Article in Pediatric radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 24 citations in OpenAlex.
- Assessment and management of low bone mineral density in children with cerebral palsy.Journal of the Pediatric Orthopaedic Society of North America · 2024Article
- The effect of low-dose intravenous bisphosphonate treatment on osteoporosis in children with quadriplegic cerebral palsy.Korean journal of pediatrics · 2017Article
- Osteoporosis in Children with Chronic Illnesses: Diagnosis, Monitoring, and Treatment.Current osteoporosis reports · 2017Review
- Fractures in children with cerebral palsy.Current osteoporosis reports · 2014Review
- Osteoclasts and hematopoiesis.BoneKEy reports · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the nonambulatory cerebral palsy (CP) population with a prior history of fracture, the use of pamidronate is not always effective in preventing further fractures.
objectiveTo test the hypothesis that when fractures occur after cyclic pamidronate, they will be at the proximal or distal end of a pamidronate band. MATERIALS AND
methodsRetrospective review of our CP patient database revealed 53 children who had received one or more complete courses of pamidronate therapy (five cycles over 12 months). Medical records were screened to identify children who had sustained a fracture or fractures after completing treatment.
resultsOf 53 patients treated with pamidronate, only 14 sustained fractures after treatment. Radiographs were available for 11 patients, showing 19 fractures. Sixty-three percent of these fractures were located at a junction with pamidronate bands but not within the bands.
conclusionsWe propose stress risers as the mechanism for fractures that have occurred where bone mineral density abruptly changes as a result of cyclic administration of pamidronate. We show a theoretical example of how alternative dosing might reduce the ratio and therefore decrease the chance of formation of a stress riser.
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Registered trials
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