ArticlePathology research international2011
Current concepts on dedifferentiation/high-grade transformation in salivary gland tumors.
Article in Pathology research international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Primary endobronchial epithelial-myoepithelial carcinoma: A case report and literature review.Experimental and therapeutic medicine · 2025Article
- Current Developments in Diagnosis of Salivary Gland Tumors: From Structure to Artificial Intelligence.Life (Basel, Switzerland) · 2024Review
- Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report.BMC medical genomics · 2022Article
- High-Grade Transformation in Adenoid Cystic Carcinoma of the Bartholin Gland: Case Report.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2021Article
- Rare Diseases of the Salivary Glands and of Facial Nerve.Laryngo- rhino- otologie · 2021Article
- Immortalization of Salivary Gland Epithelial Cells of Xerostomic Patients: Establishment and Characterization of Novel Cell Lines.Journal of clinical medicine · 2020Article
- Palatal Polymorphous Adenocarcinoma with High-Grade Transformation: A Case Report and Literature Review.Head and neck pathology · 2019Article
- Secretory carcinoma: the eastern Canadian experience and literature review.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2018Review
- Epithelial-myoepithelial carcinoma with high-grade transformation of parotid gland: A case report and literature review.Medicine · 2017Article
- Comparative histological and immunohistochemical study of ameloblastomas and ameloblastic carcinomas.Medicina oral, patologia oral y cirugia bucal · 2017Article
- Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Salivary Gland.Head and neck pathology · 2017Article
- Basaloid/blue salivary gland tumors.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Review
- Salivary gland hybrid tumour revisited: could they represent high-grade transformation in a low-grade neoplasm?Virchows Archiv : an international journal of pathology · 2016Article
- Dedifferentiated adenoid cystic carcinoma of the nasopharynx: a rare entity of head and neck cancer.BMJ case reports · 2016Article
- Clinicopathologic and Immunophenotypic Characterization of 25 Cases of Acinic Cell Carcinoma with High-Grade Transformation.Head and neck pathology · 2016Article
- Primary epithelial-myoepithelial carcinoma of the lung: A case report demonstrating high-grade transformation-like changes.Oncology letters · 2015Article
- Insight into the Evolving Concepts on the Origin of Salivary Gland Neoplasms.Journal of international oral health : JIOH · 2015Article
- Analysis of MYB oncogene in transformed adenoid cystic carcinomas reveals distinct pathways of tumor progression.Laboratory investigation; a journal of technical methods and pathology · 2014Article
- Mammary analog secretory carcinoma of salivary gland with high-grade histology arising in hard palate, report of a case and review of literature.International journal of clinical and experimental pathology · 2014Review
- Case study of a parotid gland adenocarcinoma dedifferentiated from epithelial-myoepithelial carcinoma.Case reports in otolaryngology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concept of dedifferentiation had previously been used in salivary gland carcinomas. Recently, the term "high-grade transformation" was introduced for adenoid cystic carcinoma, acinic cell carcinoma, epithelial-myoepithelial carcinoma, and polymorphous low-grade adenocarcinoma and may better reflect this phenomenon, although transformation into moderately differentiated adenocarcinoma (i.e., not "high grade") has also been described. Among the immunohistochemical markers, Ki-67 seems to be the only one that can help distinguish between the conventional and transformed components; however, the combination of morphological criteria is still sovereign. The overexpression of p53 was observed in the transformed component in all tumor types studied, despite few cases having been demonstrated to carry mutations or deletions in TP53 gene. Genetic studies in salivary gland tumors with dedifferentiation/high-grade transformation are rare and deserve further investigation. This paper aims at providing an overview on the recent concepts in histopathological classification of salivary gland tumors, complemented by immunohistochemical and genetic findings.
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