ArticleJournal of aging research2011
Age-related white matter changes.
Article in Journal of aging research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 163 citations in OpenAlex.
- White matter hyperintensities associated with small vessel disease impair social cognition beside attention and memory.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Trial
- Microbleeds in late-life depression: comparison of early- and late-onset depression.BioMed research international · 2014Trial
- Association between vascular risk factors and white matter integrity among diverse predominantly older Hispanic/Latino adults from the SOL-INCA MRI study.GeroScience · 2026Article
- Advancing clinical trial readiness in white matter disease and related dementias: key steps for future research progress.GeroScience · 2026Article
- Behçet Disease and Cognitive Impairment: A Case Study of an Overlooked Symptom.The American journal of case reports · 2025Article
- Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Leukoaraiosis: Epidemiology, Imaging, Risk Factors, and Management of Age-Related Cerebral White Matter Hyperintensities.Journal of stroke · 2024Review
- In search of subcortical and cortical morphologic alterations of a normal brain through aging: an investigation by computed tomography scan.Anatomy & cell biology · 2024Article
- Cognitive Fitness: Harnessing the Strength of Exerkines for Aging and Metabolic Challenges.Sports (Basel, Switzerland) · 2024Review
- Review
- White matter tract microstructure, macrostructure, and associated cortical gray matter morphology across the lifespan.bioRxiv : the preprint server for biology · 2023Article
- White matter tract microstructure, macrostructure, and associated cortical gray matter morphology across the lifespan.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Subiculum-BNST structural connectivity in humans and macaques.NeuroImage · 2022Article
- Relationship between Helicobacter pylori infection and white matter lesions in patients with migraine.BMC neurology · 2022Article
- Validation and test-retest repeatability performance of parametric methods for [EJNMMI research · 2022Article
- The etiologies of post-stroke depression: Different between lacunar stroke and non-lacunar stroke.Clinics (Sao Paulo, Brazil) · 2022Article
- Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment.Frontiers in neurology · 2022Review
- Brain aging mechanisms with mechanical manifestations.Mechanisms of ageing and development · 2021Review
- Spatially constrained kinetic modeling with dual reference tissues improvesEuropean journal of nuclear medicine and molecular imaging · 2021Article
- Role of Purinergic Signalling in Endothelial Dysfunction and Thrombo-Inflammation in Ischaemic Stroke and Cerebral Small Vessel Disease.Biomolecules · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related white matter changes (WMC) are considered manifestation of arteriolosclerotic small vessel disease and are related to age and vascular risk factors. Most recent studies have shown that WMC are associated with a host of poor outcomes, including cognitive impairment, dementia, urinary incontinence, gait disturbances, depression, and increased risk of stroke and death. Although the clinical relevance of WMC has been extensively studied, to date, only very few clinical trials have evaluated potential symptomatic or preventive treatments for WMC. In this paper, we reviewed the current understanding in the pathophysiology, epidemiology, clinical importance, chemical biomarkers, and treatments of age-related WMC.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.