ArticlePloS one2011
Neurodegenerative properties of chronic pain: cognitive decline in patients with chronic pancreatitis.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- The Relationship Between Chronic Pain and Neurocognitive Function: A Systematic Review.The Clinical journal of pain · 2018Pooled it
- Effects of Mindfulness-Oriented Recovery Enhancement Versus Social Support on Negative Affective Interference During Inhibitory Control Among Opioid-Treated Chronic Pain Patients: A Pilot Mechanistic Study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Trial
- Pain-specific modulation of hippocampal activity and functional connectivity during visual encoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Article
- Exploring the link between body physiology and cognition: the role of the brain and aging.npj aging · 2026Article
- Chronic pain and cognitive dysfunction: clinical manifestations, underlying mechanisms, and emerging therapeutic strategies.Frontiers in neuroscience · 2025Review
- A scoping review of neurodegenerative manifestations in explainable digital phenotyping.NPJ Parkinson's disease · 2023Article
- Relationships Between Chronic Pain Stage, Cognition, Temporal Lobe Cortex, and Sociodemographic Variables.Journal of Alzheimer's disease : JAD · 2021Article
- Sleep disorders related to nutrition and digestive diseases: a neglected clinical condition.International journal of medical sciences · 2021Review
- Electrophysiological investigation of the contribution of attention to altered pain inhibition processes in patients with irritable bowel syndrome.The journal of physiological sciences : JPS · 2020Article
- Comorbid Pain and Cognitive Impairment in a Nationally Representative Adult Population: Prevalence and Associations With Health Status, Health Care Utilization, and Satisfaction With Care.The Clinical journal of pain · 2020Article
- Anterior insular cortex mediates hyperalgesia induced by chronic pancreatitis in rats.Molecular brain · 2019Article
- Medical Management of Pain in Chronic Pancreatitis.Digestive diseases and sciences · 2017Review
- Cognitive Impairment in Patients with Chronic Neuropathic or Radicular Pain: An Interaction of Pain and Age.Frontiers in behavioral neuroscience · 2017Article
- Magnitude and variability of effect sizes for the associations between chronic pain and cognitive test performances: a meta-analysis.British journal of pain · 2016Article
- Direct Costs of Acute Recurrent and Chronic Pancreatitis in Children in the INSPPIRE Registry.Journal of pediatric gastroenterology and nutrition · 2016Article
- Vocal response inhibition is enhanced by anodal tDCS over the right prefrontal cortex.Experimental brain research · 2016Article
- Psychological Considerations in the Assessment and Treatment of Pain in Neurorehabilitation and Psychological Factors Predictive of Therapeutic Response: Evidence and Recommendations from the Italian Consensus Conference on Pain in Neurorehabilitation.Frontiers in psychology · 2016Review
- Psychological processing in chronic pain: a neural systems approach.Neuroscience and biobehavioral reviews · 2014Review
- Pain is associated with prospective memory dysfunction in multiple sclerosis.Journal of clinical and experimental neuropsychology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic pain has been associated with impaired cognitive function. We examined cognitive performance in patients with severe chronic pancreatitis pain. We explored the following factors for their contribution to observed cognitive deficits: pain duration, comorbidity (depression, sleep disturbance), use of opioids, and premorbid alcohol abuse. The cognitive profiles of 16 patients with severe pain due to chronic pancreatitis were determined using an extensive neuropsychological test battery. Data from three cognitive domains (psychomotor performance, memory, executive functions) were compared to data from healthy controls matched for age, gender and education. Multivariate multilevel analysis of the data showed decreased test scores in patients with chronic pancreatitis pain in different cognitive domains. Psychomotor performance and executive functions showed the most prominent decline. Interestingly, pain duration appeared to be the strongest predictor for observed cognitive decline. Depressive symptoms, sleep disturbance, opioid use and history of alcohol abuse provided additional explanations for the observed cognitive decline in some of the tests, but to a lesser extent than pain duration. The negative effect of pain duration on cognitive performance is compatible with the theory of neurodegenerative properties of chronic pain. Therefore, early and effective therapeutic interventions might reduce or prevent decline in cognitive performance, thereby improving outcomes and quality of life in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.