ArticlePLoS genetics2011
B chromosomes have a functional effect on female sex determination in Lake Victoria cichlid fishes.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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80 citing papers in PubMed, 163 citations in OpenAlex.
- Genome assembly of Astatotilapia latifasciata uncovers B chromosome-linked chromatin reorganization.Heredity · 2026Article
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- The evolutionary genomics of meiotic drive.Molecular biology and evolution · 2026Article
- Genome assembly of the maize B chromosome provides insight into its epigenetic characteristics and effects on the host genome.Genome biology · 2025Article
- The Hypolimnas misippus Genome Supports a Common Origin of the W Chromosome in Lepidoptera.Genome biology and evolution · 2024Article
- Diversity of Sex Chromosomes in Vertebrates: Six Novel Sex Chromosomes in Basal Haplochromines (Teleostei: Cichlidae).Genome biology and evolution · 2024Article
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- First Update to B-Chrom: A Database on B-Chromosomes.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Sex chromosomes in the tribe Cyprichromini (Teleostei: Cichlidae) of Lake Tanganyika.Scientific reports · 2022Article
- B Chromosomes inAnimals : an open access journal from MDPI · 2022Review
- Why not Y naught.Heredity · 2022Review
- Meiotic behavior, transmission and active genes of B chromosomes in the cichlid Astatotilapia latifasciata: new clues about nature, evolution and maintenance of accessory elements.Molecular genetics and genomics : MGG · 2022Article
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- Comprehending the dynamism of B chromosomes in their journey towards becoming unselfish.Frontiers in cell and developmental biology · 2022Review
- B Chromosomes' Sequences in Yellow-Necked MiceLife (Basel, Switzerland) · 2021Article
- A supernumerary "B-sex" chromosome drives male sex determination in the Pachón cavefish, Astyanax mexicanus.Current biology : CB · 2021Article
- Expanding the classical paradigm: what we have learnt from vertebrates about sex chromosome evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Dynamics of sex chromosome evolution in a rapid radiation of cichlid fishes.Science advances · 2021Article
- Genomic anatomy of male-specific microchromosomes in a gynogenetic fish.PLoS genetics · 2021Article
- The Dryas iulia Genome Supports Multiple Gains of a W Chromosome from a B Chromosome in Butterflies.Genome biology and evolution · 2021Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endemic cichlid fishes in Lake Victoria are a model system for speciation through adaptive radiation. Although the evolution of the sex-determination system may also play a role in speciation, little is known about the sex-determination system of Lake Victoria cichlids. To understand the evolution of the sex-determination system in these fish, we performed cytogenetic analysis in 11 cichlid species from Lake Victoria. B chromosomes, which are present in addition to standard chromosomes, were found at a high prevalence rate (85%) in these cichlids. In one species, B chromosomes were female-specific. Cross-breeding using females with and without the B chromosomes demonstrated that the presence of the B chromosomes leads to a female-biased sex ratio in this species. Although B chromosomes were believed to be selfish genetic elements with little effect on phenotype and to lack protein-coding genes, the present study provides evidence that B chromosomes have a functional effect on female sex determination. FISH analysis using a BAC clone containing B chromosome DNA suggested that the B chromosomes are derived from sex chromosomes. Determination of the nucleotide sequences of this clone (104.5 kb) revealed the presence of several protein-coding genes in the B chromosome, suggesting that B chromosomes have the potential to contain functional genes. Because some sex chromosomes in amphibians and arthropods are thought to be derived from B chromosomes, the B chromosomes in Lake Victoria cichlids may represent an evolutionary transition toward the generation of sex chromosomes.
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