ArticleWorld journal of gastroenterology2011
Identification of methylation profile of HOX genes in extrahepatic cholangiocarcinoma.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Epigenetic regulation of HOXA2 expression affects tumor progression and predicts breast cancer patient survival.Cell death and differentiation · 2025Article
- Epigenetic upregulation of TET2 is an independent poor prognostic factor for intrahepatic cholangiocarcinoma.Virchows Archiv : an international journal of pathology · 2022Article
- A novel DNA methylation-based model that effectively predicts prognosis in hepatocellular carcinoma.Bioscience reports · 2021Article
- An aging and p53 related marker:Aging · 2021Article
- Methylation inCells · 2020Review
- Global identification and characterization of lncRNAs that control inflammation in malignant cholangiocytes.BMC genomics · 2018Article
- Potential prognostic biomarkers identified by DNA methylation profiling analysis for patients with lung adenocarcinoma.Oncology letters · 2018Article
- Promoter hypermethylation ofClinical epigenetics · 2016Article
- DNA methylation profiling identifies novel markers of progression in hepatitis B-related chronic liver disease.Clinical epigenetics · 2016Article
- HOXD13 methylation status is a prognostic indicator in breast cancer.International journal of clinical and experimental pathology · 2015Article
- DNA methyltransferase inhibitor zebularine induces human cholangiocarcinoma cell death through alteration of DNA methylation status.PloS one · 2015Article
- Microarray-based DNA methylation study of Ewing's sarcoma of the bone.Oncology letters · 2014Article
- Methylated Bone Morphogenetic Protein 3 (BMP3) Gene: Evaluation of Tumor Suppressor Function and Biomarker Potential in Biliary Cancer.Journal of molecular biomarkers & diagnosis · 2013Article
- Genome-wide aberrant DNA methylation of microRNA host genes in hepatocellular carcinoma.Epigenetics · 2012Article
- 125I seed irradiation induces up-regulation of the genes associated with apoptosis and cell cycle arrest and inhibits growth of gastric cancer xenografts.Journal of experimental & clinical cancer research : CR · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo identify methylation profile and novel tumor marker of extrahepatic cholangiocarcinoma (CCA) with high throughout microarray.
methodsDifferential methylation profile was compared between normal bile duct epithelial cell lines and CCA cell lines by methyl-DNA immunoprecipitation (MeDIP) microarray. Bisulfite-polymerase chain reaction (BSP) was performed to identify the methylated allels of target genes. Expression of target genes was investigated before and after the treatment with DNA demethylating agent. Expression of candidate genes was also evaluated by immunofluorescence in 30 specimens of CCA tissues and 9 normal bile duct tissues.
resultsMethylation profile of CCA was identified with MeDIP microarray in the respects of different gene functions and signaling pathways. Interestingly, 97 genes with hypermethylated CpG islands in the promoter region were homeobox genes. The top 5 hypermethylated homeobox genes validated by BSP were HOXA2 (94.29%), HOXA5 (95.38%), HOXA11 (91.67%), HOXB4 (90.56%) and HOXD13 (94.38%). Expression of these genes was reactivated with 5'-aza-2'-deoxycytidine. Significant expression differences were found between normal bile duct and extrahepatic CCA tissues (66.67%-100% vs 3.33%-10%).
conclusionHOXA2, HOXA5, HOXA11, HOXB4 and HOXD13 may work as differential epigenetic biomarkers between malignant and benign biliary tissues.
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