Converging evidence for central 5-HT effects in acute tryptophan depletion.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

46 citing papers in PubMed.

1. Facial expressions of pain: the role of the serotonergic system.Psychopharmacology · 2023
   Trial
2. The effects of acute tryptophan depletion on instrumental reward learning in anorexia nervosa - an fMRI study.Psychological medicine · 2023
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3. Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans.Molecular psychiatry · 2021
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4. Effect of Tryptophan Depletion on Conditioned Threat Memory Expression: Role of Intolerance of Uncertainty.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021
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5. Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality.Translational psychiatry · 2021
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6. Reward and avoidance learning in the context of aversive environments and possible implications for depressive symptoms.Psychopharmacology · 2019
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7. Acute tryptophan loading decreases functional connectivity between the default mode network and emotion-related brain regions.Human brain mapping · 2019
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8. Measuring endogenous changes in serotonergic neurotransmission with [Translational psychiatry · 2019
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9. Effects of biperiden and acute tryptophan depletion and their combination on verbal word memory and EEG.Psychopharmacology · 2017
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10. Valence-dependent influence of serotonin depletion on model-based choice strategy.Molecular psychiatry · 2016
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11. Serotonin depletion induces 'waiting impulsivity' on the human four-choice serial reaction time task: cross-species translational significance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014
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12. The role of serotonin in the neurocircuitry of negative affective bias: serotonergic modulation of the dorsal medial prefrontal-amygdala 'aversive amplification' circuit.NeuroImage · 2013
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13. Acute tryptophan depletion in accordance with body weight: influx of amino acids across the blood-brain barrier.Journal of neural transmission (Vienna, Austria : 1996) · 2012
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14. Acute tryptophan depletion increases translational indices of anxiety but not fear: serotonergic modulation of the bed nucleus of the stria terminalis?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Trial
15. Serotonin selectively modulates reward value in human decision-making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012
    Trial
16. Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression.Biological psychiatry · 2012
    Trial
17. The influence of serotonin on fear learning.PloS one · 2012
    Trial
18. Association Between Neutrophil Percentage-to-Albumin Ratio and Depression in Middle-Aged and Elderly Adults: A National Study.Behavioural neurology · 2025
    Article
19. Direct serotonin release in humans shapes aversive learning and inhibition.Nature communications · 2024
    Article
20. The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies.Brain sciences · 2023
    Review

Corrections and comments

• Comment on
  Mechanism of acute tryptophan depletion: is it only serotonin?2011
• Erratum issued
  Campbell-Meikeljohn, D [corrected to Campbell-Meiklejohn, D]

Authors and funding

14 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as