ArticleJournal of acquired immune deficiency syndromes (1999)2011
Changing predictors of mortality over time from cART start: implications for care.
Article in Journal of acquired immune deficiency syndromes (1999), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- mHealth Interventions for Treatment Adherence and Outcomes of Care for Cardiometabolic Disease Among Adults Living With HIV: Systematic Review.JMIR mHealth and uHealth · 2021Pooled it
- Effects of undernutrition on mortality and morbidity among adults living with HIV in sub-Saharan Africa: a systematic review and meta-analysis.BMC infectious diseases · 2021Pooled it
- Marked sex differences in all-cause mortality on antiretroviral therapy in low- and middle-income countries: a systematic review and meta-analysis.Journal of the International AIDS Society · 2016Pooled it
- Retention of Adult Patients on Antiretroviral Therapy in Low- and Middle-Income Countries: Systematic Review and Meta-analysis 2008-2013.Journal of acquired immune deficiency syndromes (1999) · 2015Pooled it
- Trial
- Reclassification of risk of death with the knowledge of D-dimer in a cohort of treated HIV-infected individuals.AIDS (London, England) · 2012Trial
- Determinants of long-term survival in late HIV presenters: The prospective PISCIS cohort study.EClinicalMedicine · 2022Article
- HIV testing services in healthcare facilities in South Africa: a missed opportunity.Journal of the International AIDS Society · 2019Article
- Anemia, Iron Deficiency, and Iron Supplementation in Relation to Mortality among HIV-Infected Patients Receiving Highly Active Antiretroviral Therapy in Tanzania.The American journal of tropical medicine and hygiene · 2019Article
- Loss to follow-up from antiretroviral therapy clinics: A systematic review and meta-analysis of published studies in South Africa from 2011 to 2015.Southern African journal of HIV medicine · 2019Article
- Palliative care guidelines for the management of HIV-infected people in South Africa.Southern African journal of HIV medicine · 2019Article
- Estimating retention in HIV care accounting for patient transfers: A national laboratory cohort study in South Africa.PLoS medicine · 2018Article
- Prevalence, evolution, and related risk factors of kidney disease among Spanish HIV-infected individuals.Medicine · 2017Observational
- Chronic hepatitis B increases mortality and complexity among HIV-coinfected patients in South Africa: a cohort study.HIV medicine · 2016Article
- HIV and tuberculosis in prisons in sub-Saharan Africa.Lancet (London, England) · 2016Review
- Anemia and Red Blood Cell Indices Predict HIV-Associated Neurocognitive Impairment in the Highly Active Antiretroviral Therapy Era.The Journal of infectious diseases · 2016Article
- Systematic review and meta-analysis of the adolescent HIV continuum of care in South Africa: the Cresting Wave.BMJ global health · 2016Article
- Treatment Failure, Drug Resistance, and CD4 T-Cell Count Decline Among Postpartum Women on Antiretroviral Therapy in South Africa.Journal of acquired immune deficiency syndromes (1999) · 2016Observational
- A Comparison of Seven Cox Regression-Based Models to Account for Heterogeneity Across Multiple HIV Treatment Cohorts in Latin America and the Caribbean.AIDS research and human retroviruses · 2015Article
- When are patients lost to follow-up in pre-antiretroviral therapy care? a retrospective assessment of patients in an Ethiopian rural hospital.Infectious diseases of poverty · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveTo determine predictors of mortality and changes in those predictors over time on combination antiretroviral therapy (cART) in South Africa.
designA cohort study.
methodsUsing routine clinic data with up to 4 years follow-up after antiretroviral therapy initiation and with death ascertainment from a national vital statistics register, we used proportional hazards modeling to assess baseline and time-updated predictors of mortality and changes in strength of those predictors over time on cART. Furthermore, we compared CD4 count among individuals who died by duration on cART.
resultsFifteen thousand sixty subjects (64% men, median CD4 count 127 cells/mm³) started antiretroviral therapy between January 2003 and January 2008. Over a median follow-up of 1.8 years, 2658 subjects died. The baseline characteristics of WHO stage, hemoglobin, CD4 count, HIV RNA level, and symptoms were all associated with mortality during the first 12 months of cART but lost association thereafter. However, time-updated factors of CD4 count, body mass index, symptoms, anemia, and HIV RNA suppression remained strong predictors of death. Most recent CD4 count before death rose from 71 during the first 3 months of cART to 175 cells per cubic millimeter after >3 years of cART.
conclusionOver 4 years of cART, risk of death declined and associations with mortality changed. An increase in CD4 count at death and changing associations with mortality may suggest a shift in causes of death, possibly from opportunistic infections to other infections and chronic illnesses.
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