ArticleProceedings of the National Academy of Sciences of the United States of America2011
Two types of cis-trans compensation in the evolution of transcriptional regulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Human gene regulatory evolution is driven by the divergence of regulatory element function in both cis and trans.Cell genomics · 2024Article
- Non-additive genetic components contribute significantly to population-wide gene expression variation.Cell genomics · 2024Article
- Non-additive genetic components contribute significantly to population-wide gene expression variation.bioRxiv : the preprint server for biology · 2023Article
- Regulatory Divergence as a Mechanism for X-Autosome Incompatibilities in Caenorhabditis Nematodes.Genome biology and evolution · 2023Article
- Expression inheritance and constraints on cis- and trans-regulatory mutations underlying lotus color variation.Plant physiology · 2023Article
- Nonadditive and allele-specific expression of ghrelin in hybrid tilapia.Frontiers in endocrinology · 2023Article
- Environmental factors have a major effect in shaping the gene expression of Siberian larch in the Altai Mountains of China.The plant genome · 2022Article
- Extensive transgressive gene expression in testis but not ovary in the homoploid hybrid Italian sparrow.Molecular ecology · 2022Article
- Interspecific hybridization as a driver of fungal evolution and adaptation.Nature reviews. Microbiology · 2021Review
- Speciation and the developmental alarm clock.eLife · 2020Review
- Rampant Misexpression in a Mimulus (Monkeyflower) Introgression Line Caused by Hybrid Sterility, Not Regulatory Divergence.Molecular biology and evolution · 2020Article
- Hybrid gene misregulation in multiple developing tissues within a recent adaptive radiation of Cyprinodon pupfishes.PloS one · 2019Article
- The Evolution of Gene Expression in cis and trans.Trends in genetics : TIG · 2018Review
- Evolutionary Dynamics of Regulatory Changes Underlying Gene Expression Divergence among Saccharomyces Species.Genome biology and evolution · 2017Article
- Gene Regulation and Speciation.Trends in genetics : TIG · 2017Review
- Article
- Transcriptome shock invokes disruption of parental expression-conserved genes in tetraploid wheat.Scientific reports · 2016Article
- The Drosophila bag of marbles Gene Interacts Genetically with Wolbachia and Shows Female-Specific Effects of Divergence.PLoS genetics · 2015Article
- Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression.BMC genomics · 2012Article
- Coevolution within and between regulatory loci can preserve promoter function despite evolutionary rate acceleration.PLoS genetics · 2012Article
Corrections and comments
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because distant species often share similar macromolecules, regulatory mutations are often considered responsible for much of their biological differences. Recently, a large portion of regulatory changes has been attributed to cis-regulatory mutations. Here, we examined an alternative possibility that the putative contribution of cis-regulatory changes was, in fact, caused by compensatory action of cis- and trans-regulatory elements. First, we show by stochastic simulations that compensatory cis-trans evolution maintains the binding affinity of a transcription factor at a constant level, thereby spuriously exaggerating the contribution of cis-regulatory mutations to gene expression divergence. This exaggeration was not observed when changes in the binding affinity were compensated by variable transcription factor concentration. Second, using reciprocal introgressions of Drosophila, we show that relative expression of heterozygous alleles from two distinct species often varied significantly between different species backgrounds, indicating the possible action of cis-trans compensation. Taken together, we propose that cis-trans hybrid incompatibilities are accumulating much faster than generally considered.
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