ArticleThe Journal of pharmacology and experimental therapeutics2011
Acute oxycodone induces the pro-emetic pica response in rats.
Article in The Journal of pharmacology and experimental therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Neurobehavioral Characterization of Perinatal Oxycodone-Exposed Offspring in Early Adolescence.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024Article
- Evaluating proxies for motion sickness in rodent.IBRO neuroscience reports · 2023Article
- Intranasal ondansetron microemulsion counteracting the adverse effects of cisplatin: animal study.Pharmacological reports : PR · 2023Article
- Study of the Mechanism of Antiemetic Effect ofDrug design, development and therapy · 2022Article
- Effects of sedative psychotropic drugs combined with oxycodone on respiratory depression in the rat.Clinical and translational science · 2021Article
- Sexually dimorphic neuroimmune response to chronic opioid treatment and withdrawal.Neuropharmacology · 2021Article
- Article
- Isoflurane induces c-Fos expression in the area postrema of the rat.Journal of anesthesia · 2019Article
- Possible involvement of central oxytocin in cisplatin-induced anorexia in rats.The journal of physiological sciences : JPS · 2018Article
- Intranasally administered in situ gelling nanocomposite system of dimenhydrinate: preparation, characterization and pharmacodynamic applicability in chemotherapy induced emesis model.Scientific reports · 2017Article
- Lack of adverse effects during a target animal safety trial of extended-release buprenorphine in Fischer 344 rats.Lab animal · 2016Article
- Chronic oxycodone induces integrated stress response in rat brain.BMC neuroscience · 2015Article
- Evaluating the various phases of cisplatin-induced emesis in rats.Oncology letters · 2014Article
- Effect of yohimbine stress on reacquisition of oxycodone seeking in rats.Psychopharmacology · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Oxycodone, a semisynthetic opioid analgesic, is frequently prescribed for the management of pain. Side effects of nausea and emesis affect patient compliance and limit its therapeutic use. The present study established that an antinociceptive dose of oxycodone (15 mg/kg; oral) induces the pica response. We found sex differences in the temporal course of pica, with females having a longer duration. Opioid receptors mediated the pica response, as 1.0 mg/kg naloxone transiently attenuated and 2.0 mg/kg naloxone blocked pica. A κ-selective antagonist failed to block the response, suggesting mediation by μ opioid receptor. For further validation, we used the well established kaolin intake model to assess pica with the chemotherapeutic drug cisplatin as a positive control. Oxycodone and cisplatin significantly increased kaolin intake 4- to 7-fold, and the wet weight of stomach was elevated 2- to 3-fold. To examine the underlying neural circuitry, we investigated c-fos activation in the area postrema and nucleus of solitary tract (NTS). Oxycodone treatment significantly increased the number of c-fos-positive neurons in the area postrema and NTS compared with water controls. As expected, cisplatin also increased the number of c-fos-positive cells in these regions. In the area postrema, the oxycodone effect was greater than cisplatin, especially at 2 h. These results indicate that an antinociceptive dose of oxycodone is associated with the expression of pica, a pro-emetic response.
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