ReviewHuman molecular genetics2011
Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour.
Review in Human molecular genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 7 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Association between chemokine CXC ligand 12 gene polymorphism (rs1746048) and coronary heart disease: A MOOSE-compliant meta-analysis.Medicine · 2017Pooled it
- Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.Nature communications · 2015Pooled it
- GWAS-identified loci for coronary heart disease are associated with intima-media thickness and plaque presence at the carotid artery bulb.Atherosclerosis · 2015Pooled it
- A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.Human molecular genetics · 2014Pooled it
- Apolipoprotein A5 gene variants and the risk of coronary heart disease: a case‑control study and meta‑analysis.Molecular medicine reports · 2013Pooled it
- Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.Nature genetics · 2012Pooled it
- Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect.PloS one · 2012Pooled it
- Polymorphic and Expressional Analysis of GenesInternational journal of hypertension · 2025Article
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- Associations of ARHGAP26 Polymorphisms with Alzheimer's Disease and Cardiovascular Disease.Journal of molecular neuroscience : MN · 2022Article
- Why Do High-Risk Patients Develop or Not Develop Coronary Artery Disease? Metabolic Insights from the CAPIRE Study.Metabolites · 2022Article
- Association of rs2954029 and rs6982502 Variants with Coronary Artery Disease by HRM Technique: A GWAS Replication Study in an Iranian Population.Reports of biochemistry & molecular biology · 2022Article
- Effects of High-Fat Diet Induced Obesity and Fructooligosaccharide Supplementation on Cardiac Protein Expression.Nutrients · 2020Article
- Article
- Interaction between Coffee Drinking and TRIB1 rs17321515 Single Nucleotide Polymorphism on Coronary Heart Disease in a Taiwanese Population.Nutrients · 2020Article
- Moral reasons to edit the human genome: picking up from the Nuffield report.Journal of medical ethics · 2019Article
- TRIB1 and TRPS1 variants, G × G and G × E interactions on serum lipid levels, the risk of coronary heart disease and ischemic stroke.Scientific reports · 2019Article
- Genome-wide association study of coronary artery calcification in asymptomatic Korean populations.PloS one · 2019Article
- Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease.International journal of molecular medicine · 2018Article
- Identification of 26 novel loci that confer susceptibility to early-onset coronary artery disease in a Japanese population.Biomedical reports · 2018Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Coronary artery disease (CAD) is the leading cause of death worldwide. Affected individuals cluster in families in patterns that reflect the sharing of numerous susceptibility genes. Genome-wide and large-scale gene-centric genotyping studies that involve tens of thousands of cases and controls have now mapped common disease variants to 34 distinct loci. Some coronary disease common variants show allelic heterogeneity or copy number variation. Some of the loci include candidate genes that imply conventional or emerging risk factor-mediated mechanisms of disease pathogenesis. Quantitative trait loci associations with risk factors have been informative in Mendelian randomization studies as well as fine-mapping of causative variants. But, for most loci, plausible mechanistic links are uncertain or obscure at present but provide potentially novel directions for research into this disease's pathogenesis. The common variants explain ~4% of inter-individual variation in disease risk and no more than 13% of the total heritability of coronary disease. Although many CAD genes are presently undiscovered, it is likely that larger collaborative genome-wide association studies will map further common/low-penetrance variants and hoped that low-frequency or rare high-penetrance variants will also be identified in medical resequencing experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.