Evidence map›Paper›PMID 21875658›Full record

ReviewHearing research2011

Physiopathology of the cochlear microcirculation.

Xiaorui Shi

Abstract readReview
In one paragraph

Review in Hearing research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 3 syntheses or guidelines pooled it, 221 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Non-invasive intraoperative monitoring of cochlear function by cochlear microphonics during cerebellopontine-angle surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018
    Trial
  6. Article
  7. Article
  8. Article
  9. Subclinical hearing loss in women with polycystic ovary syndrome: a case-control study using extended high-frequency audiometry.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  10. Review
  11. Article
  12. Effect of the position and volume of vestibular schwannoma on hearing threshold at diagnosis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  13. Article
  14. Article
  15. Migraine Features in Patients With Sudden Sensorineural Hearing Loss.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Xiaorui ShiOregon Hearing Research Center (NRC04), Department of Otolaryngology/Head & Neck Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Shix@ohsu.edu
Oregon Health & Science University · US

Funding

PORTLAND AREA COMMUNICATION RESEARCH CORE CENTERP30DC005983 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI NUTTALL, ALFRED L · 2003 to 2017
$9.0M
CONTROL OF INNER EAR MICROCIRULATIONR01DC000105 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NUTTALL, ALFRED L · 1989 to 2017
$7.6M
Fibrovascular coupling in the cochlea and pericyte recruitment after noiseR01DC010844 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHI, XIAORUI · 2010 to 2014
$1.9M
The role of cochlear pericytes in control of cochlear microcirculationR03DC008888 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHI, XIAORUI · 2007 to 2009
$519k
AUDITORY PATHWAYS IN VOCAL LEARNING AND PERCEPTIONF32DC000105 · NIDCD · UNIVERSITY OF MARYLAND COLLEGE PK CAMPUS · PI DURAND, SARAH E · 1994 to 1996
–
NIDCD NIH HHS DC008888S1NIDCD NIH HHS F32 DC000105NIDCD NIH HHS P30 DC005983NIDCD NIH HHS P30-DC005983.DC 00105NIDCD NIH HHS R01 DC000105NIDCD NIH HHS R01 DC00105NIDCD NIH HHS R01 DC010844NIDCD NIH HHS R03 DC008888NIDCD NIH HHS R03-DC008888PHS HHS R01-NIDCD DC010844
6 · The paper itself

Abstract

Normal blood supply to the cochlea is critically important for establishing the endocochlear potential and sustaining production of endolymph. Abnormal cochlear microcirculation has long been considered an etiologic factor in noise-induced hearing loss, age-related hearing loss (presbycusis), sudden hearing loss or vestibular function, and Meniere's disease. Knowledge of the mechanisms underlying the pathophysiology of cochlear microcirculation is of fundamental clinical importance. A better understanding of cochlear blood flow (CoBF) will enable more effective management of hearing disorders resulting from aberrant blood flow. This review focuses on recent discoveries and findings related to the physiopathology of the cochlear microvasculature.

Indexed as

MicrocirculationAnimalsCochleaHearing DisordersHumansMicrovesselsRegional Blood Flow

Identifiers

PMID21875658
PMCPMC3608480
OpenAlexW2155407562

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.