Evidence map›Paper›PMID 21875225›Full record

ReviewExperimental and clinical psychopharmacology2012

Contributions of neuroimaging to understanding sex differences in cocaine abuse.

Monica L Andersen, Eileen K Sawyer, Leonard L Howell

Abstract readReview
In one paragraph

Review in Experimental and clinical psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Sex Differences in Histamine Regulation of Striatal Dopamine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  2. Article
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  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Sex differences, gender and addiction.Journal of neuroscience research · 2017
    Review
  12. Article
  13. Article
  14. Review
  15. Gender Considerations in Addiction: Implications for Treatment.Current treatment options in psychiatry · 2015
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Monica L AndersenYerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Eileen K Sawyer
Leonard L Howell
Emory University · US

Funding

YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
COCAINE USE AND MONOAMINE FUNCTION IN NONHUMAN PRIMATESR01DA012514 · NIDA · EMORY UNIVERSITY · PI HOWELL, LEONARD L · 2000 to 2014
$5.5M
PET Imaging and Cocaine Neuropharmacology in MonkeysR37DA010344 · NIDA · EMORY UNIVERSITY · PI HOWELL, LEONARD L · 2007 to 2015
$4.9M
Training Program in Neurobiology of Drug AbuseT32DA015040 · NIDA · EMORY UNIVERSITY · PI KUHAR, MICHAEL J · 2003 to 2012
$3.6M
PET IMAGING AND COCAINE NEUROPHARMACOLOGY IN MONKEYSR01DA010344 · NIDA · EMORY UNIVERSITY · PI HOWELL, LEONARD L · 1997 to 2006
$2.7M
The mt-DNA mutator mouseZ01DA000517 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI HOFFER, BARRY J · 2007 to 2008
$1.1M
Neuropharmacology of Cocaine in Nonhuman PrimatesK02DA000517 · NIDA · EMORY UNIVERSITY · PI HOWELL, LEONARD L · 2001 to 2010
$1.1M
Neuropharmacology of Abused Stimulants in Nonhuman PrimatesK05DA031246 · NIDA · EMORY UNIVERSITY · PI HOWELL, LEONARD L · 2012 to 2016
$619k
Intramural NIH HHS Z01 DA000517NCRR NIH HHS P51 RR000165NCRR NIH HHS RR00165NIDA NIH HHS DA10344NIDA NIH HHS DA12514NIDA NIH HHS K02 DA000517NIDA NIH HHS K05 DA031246NIDA NIH HHS R01 DA010344NIDA NIH HHS R01 DA012514NIDA NIH HHS R37 DA010344NIDA NIH HHS T32 DA015040NIDA NIH HHS T32-DA015040
6 · The paper itself

Abstract

A consistent observation in drug abuse research is that males and females show differences in their response to drugs of abuse. In order to understand the neurobiology underlying cocaine abuse and effective treatments, it is important to consider the role of sex differences. Sex hormones have been investigated in both behavioral and molecular studies, but further evidence addressing drug abuse and dependence in both sexes would expand our knowledge of sex differences in response to drugs of abuse. Neuroimaging is a powerful tool that can offer insight into the biological bases of these differences and meet the challenges of directly examining drug-induced changes in brain function. As such, neuroimaging has drawn much interest in recent years. Specifically, positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) technology have emerged as effective noninvasive approaches for human and animal models. Studies have revealed sex-specific changes in patterns of brain activity in response to acute cocaine injection and after prolonged cocaine use. SPECT and PET studies have demonstrated changes in the dopamine transporter but are less clear on other components of the dopaminergic system. This review highlights contributions of neuroimaging toward understanding the role of sex differences in the drug abuse field, specifically regarding cocaine, and identifies relevant questions that neuroimaging can effectively address.

Indexed as

Sex CharacteristicsAnimalsBrainCocaine-Related DisordersFemaleGonadal Steroid HormonesHumansMagnetic Resonance ImagingMaleNeuroimagingPositron-Emission TomographyTomography, Emission-Computed, Single-PhotonGonadal Steroid Hormones

Identifiers

PMID21875225
PMCPMC3269558
OpenAlexW2007605787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.