Evidence map›Paper›PMID 21875065›Full record

ArticleThe Journal of organic chemistry2011

Regio- and stereoselective syntheses of the natural product CCR5 antagonist anibamine and its three olefin isomers.

Feng Zhang, Saheem Zaidi, Kendra M Haney, Glen E Kellogg, Yan Zhang

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Feng ZhangDepartment of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States.
Saheem Zaidi
Kendra M Haney
Glen E Kellogg
Yan Zhang

Funding

Anibamine, a novel CCR5 antagonist as anti-HIV lead compoundR21AI074461 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI ZHANG, YAN · 2008 to 2009
$433k
Chemokine receptor CCR5 antagonists as novel anti-HIV agentsR03AI069975 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI ZHANG, YAN · 2006 to 2007
$147k
NIAID NIH HHS AI074461NIAID NIH HHS R03 AI069975NIAID NIH HHS R21 AI074461
6 · The paper itself

Abstract

The syntheses of the natural product anibamine and its three olefin isomers have been achieved concisely and efficiently via highly regio- and stereoselective reactions. The crucial steps included a regioselective palladium-catalyzed alkynylation by Sonogashira coupling and a stereoselective Suzuki coupling. Further conformation analyses and in vitro calcium mobilization studies were carried out to characterize the compounds' biological properties.

Indexed as

CCR5 Receptor AntagonistsAlkenesBiological ProductsCell LineIsomerismModels, MolecularMolecular ConformationPyridinesStereoisomerismSubstrate SpecificityAlkenesanibamineBiological ProductsCCR5 Receptor AntagonistsPyridines

Identifiers

PMID21875065
PMCPMC3197777

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.