ReviewJournal of neuro-oncology2012
Novel approaches to treating leptomeningeal metastases.
Review in Journal of neuro-oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03082144 (Involved-field Radiotherapy Combined With Concurrent Intrathecal-MTX Versus Intrathecal-Ara-C for Leptomeningeal Metastases From Solid Tumor), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Involved-field Radiotherapy Combined With Concurrent Intrathecal-MTX Versus Intrathecal-Ara-C for Leptomeningeal Metastases From Solid Tumor: A Randomized Phase II Clinical Trial
Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Phase II trial of temozolomide for leptomeningeal metastases in patients with solid tumors.Journal of neuro-oncology · 2012Trial
- Lumbar-ventricular cerebrospinal fluid pressure discrepancy in leptomeningeal metastasis associated intracranial hypertension.Fluids and barriers of the CNS · 2026Article
- Different methods of cerebrospinal fluid diversion in patients with leptomeningeal metastasis: A systematic review and meta-analysis.Surgical neurology international · 2025Review
- Oncolytic HSV1 targets different growth phases of breast cancer leptomeningeal metastases.Cancer gene therapy · 2023Article
- Exploring the role of cerebrospinal fluid as analyte in neurologic disorders.Future science OA · 2023Review
- A case report of endometrial adenocarcinoma with leptomeningeal metastases.Clinical case reports · 2021Article
- Neoplastic meningitis due to colorectal cancer.Clinical journal of gastroenterology · 2020Article
- Leptomeningeal metastases arising from gynecological cancers.International journal of clinical oncology · 2020Article
- Leptomeningeal Carcinomatosis from Squamous Cell Carcinoma of the Ethmoid Sinus: A Case Report.Cureus · 2019Article
- Evidence for intrathecal sodium butyrate as a novel option for leptomeningeal metastasis.Journal of neuro-oncology · 2018Article
- Review
- Leptomeningeal carcinomatosis associated with papillary renal cell carcinoma.Ecancermedicalscience · 2014Article
- Neuro-ophthalmologic complications of neoplastic leptomeningeal disease.Current neurology and neuroscience reports · 2013Review
- Breast cancer and leptomeningeal disease (LMD): hormone receptor status influences time to development of LMD and survival from LMD diagnosis.Journal of neuro-oncology · 2013Article
- A retrospective case series of 103 consecutive patients with leptomeningeal metastasis and breast cancer.Journal of neuro-oncology · 2013Article
- Leptomeningeal metastases from genitourinary cancer: the University of Texas MD Anderson Cancer Center experience.Medical oncology (Northwood, London, England) · 2013Article
- Neoplastic meningitis from solid tumors: a prospective clinical study in lombardia and a literature review on therapeutic approaches.Journal of drug delivery · 2013Article
- Carcinomatous meningitis: Leptomeningeal metastases in solid tumors.Surgical neurology international · 2013Article
- Optical detection and virotherapy of live metastatic tumor cells in body fluids with vaccinia strains.PloS one · 2013Article
- MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity.Neuro-oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Leptomeningeal metastasis is a devastating complication of the central nervous system in patients with late-stage solid or hematological cancers. Leptomeningeal metastasis results from the multifocal seeding of the leptomeninges by malignant cancer cells. Although central nervous system metastasis usually presents in patients with widely disseminated and progressive late-stage cancer, malignant cells may spread to the cerebrospinal fluid during earlier disease stages in particularly aggressive cancers. Treatment of leptomeningeal metastasis is largely palliative but will often provide stabilization and protection from further neurological deterioration and improve quality of life. There is a need to raise awareness of the impact of leptomeningeal metastases on cancer patients and its known and putative biological basis. Novel diagnostic approaches include identification of biomarkers that may stratify the risk for developing leptomeningeal metastasis. Current therapies can be used more effectively while waiting for advanced treatments to be developed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.