ArticleMolecular imaging and biology2012
A multimode optical imaging system for preclinical applications in vivo: technology development, multiscale imaging, and chemotherapy assessment.
Article in Molecular imaging and biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
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- Intelligent smartphone-based multimode imaging otoscope for the mobile diagnosis of otitis media.Biomedical optics express · 2021Article
- Biomedical Applications of Translational Optical Imaging: From Molecules to Humans.Molecules (Basel, Switzerland) · 2021Review
- Porphyrinoid Drug Conjugates.Chem · 2020Article
- Theory and design of Schwarzschild scan objective for Optical Coherence Tomography.Optics express · 2019Article
- Multimodal molecular 3D imaging for the tumoral volumetric distribution assessment of folate-based biosensors.Medical & biological engineering & computing · 2018Article
- Review of quantitative multiscale imaging of breast cancer.Journal of medical imaging (Bellingham, Wash.) · 2018Review
- A Multimodal Biomicroscopic System based on High-frequency Acoustic Radiation Force Impulse and Multispectral Imaging Techniques for Tumor Characterization Ex vivo.Scientific reports · 2017Article
- Ultrafast Dynamics of Sb-Corroles: A Combined Vis-Pump Supercontinuum Probe and Broadband Fluorescence Up-Conversion Study.Molecules (Basel, Switzerland) · 2017Article
- Fighting Cancer with Corroles.Chemical reviews · 2017Review
- Ultrafast electronic and vibrational dynamics in brominated aluminum corroles: Energy relaxation and triplet formation.Structural dynamics (Melville, N.Y.) · 2016Article
- Analysis of targeted viral protein nanoparticles delivered to HER2+ tumors.Journal of visualized experiments : JoVE · 2013Article
- Development of adenovirus capsid proteins for targeted therapeutic delivery.Therapeutic delivery · 2013Review
- Photoexcitation of tumor-targeted corroles induces singlet oxygen-mediated augmentation of cytotoxicity.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
- Chemotherapy targeting by DNA capture in viral protein particles.Nanomedicine (London, England) · 2012Article
- Multimodality imaging in vivo for preclinical assessment of tumor-targeted doxorubicin nanoparticles.PloS one · 2012Article
- A spectroscopic and theoretical investigation of a free-base meso-trithienylcorrole.Photochemistry and photobiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeSeveral established optical imaging approaches have been applied, usually in isolation, to preclinical studies; however, truly useful in vivo imaging may require a simultaneous combination of imaging modalities to examine dynamic characteristics of cells and tissues. We developed a new multimode optical imaging system designed to be application-versatile, yielding high sensitivity, and specificity molecular imaging. PROCEDURES: We integrated several optical imaging technologies, including fluorescence intensity, spectral, lifetime, intravital confocal, two-photon excitation, and bioluminescence, into a single system that enables functional multiscale imaging in animal models.
resultsThe approach offers a comprehensive imaging platform for kinetic, quantitative, and environmental analysis of highly relevant information, with micro-to-macroscopic resolution. Applied to small animals in vivo, this provides superior monitoring of processes of interest, represented here by chemo-/nanoconstruct therapy assessment.
conclusionsThis new system is versatile and can be optimized for various applications, of which cancer detection and targeted treatment are emphasized here.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.