ReviewMedical science monitor : international medical journal of experimental and clinical research2011
Serotonin reuptake inhibitor antidepressants (SSRIs) against atherosclerosis.
Review in Medical science monitor : international medical journal of experimental and clinical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Association of SSRI and SNRI use with incidence of cardiovascular events in veterans with giant cell arteritis and polymyalgia rheumatica.Frontiers in immunology · 2025Article
- Cardiovascular disease and depression: a bidirectional relationship and its clinical implications.Frontiers in psychiatry · 2025Review
- Cardiovascular disease and depression: a narrative review.Frontiers in cardiovascular medicine · 2023Review
- Review
- Citalopram in the treatment of elderly chronic heart failure combined with depression: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- Review
- The Risk of Fatal Arrhythmias Associated With Sertraline in Patients With Post-myocardial Infarction Depression.Cureus · 2022Review
- Potential Role of the Antidepressants Fluoxetine and Fluvoxamine in the Treatment of COVID-19.International journal of molecular sciences · 2022Review
- Model Placental Barrier Phenotypic Response to Fluoxetine and Sertraline: A Comparative Study.Advanced healthcare materials · 2019Article
- Vascular dysfunction across the stages of the menopausal transition is associated with menopausal symptoms and quality of life.Menopause (New York, N.Y.) · 2018Article
- Evidence for cardiotoxicity associated with sertraline in rats.Toxicology research · 2018Article
- Serotonergic Antidepressants Are Associated with Increased Blood Loss and Risk for Transfusion in Single-Level Lumbar Fusion Surgery.Asian spine journal · 2017Article
- The impact of treatment with selective serotonin reuptake inhibitors on primate cardiovascular disease, behavior, and neuroanatomy.Neuroscience and biobehavioral reviews · 2017Review
- Antidepressant Use and Subclinical Measures of Atherosclerosis: The Multi-Ethnic Study of Atherosclerosis.Journal of clinical psychopharmacology · 2016Article
- Selective serotonin reuptake inhibitors and cardiovascular events: A systematic review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Review
- Functional constituents of a local serotonergic system, intrinsic to the human coronary artery smooth muscle cells.Molecular biology reports · 2015Article
- Effects of long-term sertraline treatment and depression on coronary artery atherosclerosis in premenopausal female primates.Psychosomatic medicine · 2015Article
- Effects of antidepressants on IP-10 production in LPS-activated THP-1 human monocytes.International journal of molecular sciences · 2014Article
- Inflammatory markers in patients with internal carotid artery stenosis.Archives of medical science : AMS · 2013Article
- Reduction in atherosclerotic events: a retrospective study in an outpatient cardiology practice.Archives of medical science : AMS · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selective serotonin reuptake inhibitors (SSRIs) are a class of drug widely used for treatment of mood disorders, including depression and cardiovascular disease. A search for related articles in the PubMed database was attempted. It covered studies, reports, reviews and editorials of the last 5 years. Pro-inflammatory cytokines, such as TNF-α, IL-1 and IL-6, stimulate central serotonin (5-HT) neurotransmission and are over-expressed in depression, which has been linked with hypothalamic-pituitary-adrenal axis (HPA) hyperactivity. They have also been implicated in the pathogenesis and progression of other stress-induced disorders, like myocardial infarction (MI) and coronary heart disease (CHD), as they seem to modulate cardiovascular function by a variety of mechanisms. Biological mechanisms like these may explain the link between depression and CHD. There are a variety of environmental factors as well as genetic factors that might influence the pharmacogenetics of antidepressant drugs. New generation selective serotonin reuptake inhibitor antidepressants (SSRIs) causing a reduced cardiovascular morbidity and mortality may be related to serotonin platelet abnormalities in depressed patients that are effectively treated by SSRIs. SSRIs such as fluoxetine, paroxetine, sertraline and citalopram are not only considered to be free from the cardiotoxicity of their predecessors but also to function as safe and efficacious agents against depression, platelet activation, atherosclerosis and development and prognosis of coronary heart disease. However, there is a need for more studies in order to establish the exact biochemical mechanisms that are responsible for these diseases and the immunoregulatory effects of chronic use of SSRI medications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.