ArticleMedical science monitor : international medical journal of experimental and clinical research2011
The re-infection rate of high-risk HPV and the recurrence rate of vulvar intraepithelial neoplasia (VIN) usual type after surgical treatment.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Safety and immunogenicity of VGX-3100 formulations in a healthy young adult population.Human vaccines & immunotherapeutics · 2020Trial
- Evaluating the effectiveness of various treatment modalities in vulvar high-grade squamous intraepithelial lesions (vHSIL): a systematic review.Gynecologic oncology reports · 2026Article
- Vulval premalignant lesions: a review article.Obstetrics & gynecology science · 2024Article
- miR-375 Modulates Radiosensitivity of HR-HPV-Positive Cervical Cancer Cells by Targeting UBE3A through the p53 Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Disease progression and recurrence in women treated for vulvovaginal intraepithelial neoplasia.Journal of gynecologic oncology · 2013Article
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Authors and funding
10 authors.
Funding
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Abstract
backgroundVIN usual type appears to be related to the HPV's oncogenic types. The aim of this prospective multicenter study was to evaluate the re-infection rate of high-risk HPV and the recurrence rate of VIN usual type after surgical treatment. MATERIAL/
methodsThe study enrolled 103 women affected by VIN usual type. They underwent wide local excision by CO2 laser. The patients were investigated by clinical evaluation and HPV DNA test 6 months after surgical treatment, and then were followed-up at 12, 18, 24, and 36 months. The recurrences were treated with re-excision.
resultsThe rate of HPV infection after surgical treatment was 34% at 6 months, 36.9% at 12 months, 40% at 18 months, 41.7% at 24 months and 44.7% at 36 months. The mean time from HPV infection to the development of VIN was 18.8 months.
conclusionsHPV testing in the follow-up of VIN usual type patients might be useful for identifying those patients with a higher risk of recurrence after surgical treatment, although more studies are needed. These preliminary data suggest that the test, in addition to clinical examination, can improve the efficacy of the follow-up.
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