ArticleInvestigative ophthalmology & visual science2011
Quantification of peripapillary sparing and macular involvement in Stargardt disease (STGD1).
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Review
- Bisretinoids as a Source of Early Photoreceptor Pathology in Stargardt Disease.Ophthalmic research · 2025Review
- Functional Characterization of ABCA4 Missense Variants Aids Variant Interpretation and Phenotype Prediction in Patients With ABCA4-Retinal Dystrophies.Investigative ophthalmology & visual science · 2024Article
- Electroretinography as a Biomarker to Monitor the Progression of Stargardt Disease.International journal of molecular sciences · 2022Article
- Investigation of Structural Alterations in Inherited Retinal Diseases: A Quantitative SD-OCT-Analysis of Retinal Layer Thicknesses in Light of Underlying Genetic Mutations.International journal of molecular sciences · 2022Article
- Novel disease-causing variant inThe British journal of ophthalmology · 2022Article
- Retrospective Natural History Study ofInternational journal of molecular sciences · 2022Article
- DeepRetina: Layer Segmentation of Retina in OCT Images Using Deep Learning.Translational vision science & technology · 2020Article
- Prediction of Function in ABCA4-Related Retinopathy Using Ensemble Machine Learning.Journal of clinical medicine · 2020Article
- Monitoring and Management of the Patient with Stargardt Disease.Clinical optometry · 2019Review
- Peripapillary sparing in RDH12-associated Leber congenital amaurosis.Ophthalmic genetics · 2017Article
- A Comparison of En Face Optical Coherence Tomography and Fundus Autofluorescence in Stargardt Disease.Investigative ophthalmology & visual science · 2017Article
- Insights into autofluorescence patterns in Stargardt macular dystrophy using ultra-wide-field imaging.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Observational
- Electroretinography Reveals Difference in Cone Function between Syndromic and Nonsyndromic USH2A Patients.Scientific reports · 2017Article
- MAPPING THE DENSE SCOTOMA AND ITS ENLARGEMENT IN STARGARDT DISEASE.Retina (Philadelphia, Pa.) · 2016Article
- Recessive Stargardt disease phenocopying hydroxychloroquine retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016Observational
- Objective Analysis of Hyperreflective Outer Retinal Bands Imaged by Optical Coherence Tomography in Patients With Stargardt Disease.Investigative ophthalmology & visual science · 2015Article
- Near-infrared autofluorescence: its relationship to short-wavelength autofluorescence and optical coherence tomography in recessive stargardt disease.Investigative ophthalmology & visual science · 2015Article
- Quantitative classification of eyes with and without intermediate age-related macular degeneration using optical coherence tomography.Ophthalmology · 2014Article
- Fundus-driven perimetry (microperimetry) compared to conventional static automated perimetry: similarities, differences, and clinical applications.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2013Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo quantify and compare structure and function across the macula and peripapillary area in Stargardt disease (STGD1).
methodsTwenty-seven patients (27 eyes) and 12 age-similar controls (12 eyes) were studied. Patients were classified on the basis of full-field electroretinogram (ERG) results: Fundus autofluorescence (FAF) and spectral domain-optical coherence tomography (SD-OCT) horizontal line scans were obtained through the fovea and peripapillary area. The thicknesses of the outer nuclear layer plus outer plexiform layer (ONL+), outer segment (OS), and retinal pigment epithelium (RPE) were measured through the fovea, and peripapillary areas from 1° to 4° temporal to the optic disc edge using a computer-aided, manual segmentation technique. Visual sensitivities in the central 10° were assessed using microperimetry and related to retinal layer thicknesses.
resultsCompared to the central macula, the differences between controls and patients in ONL+, OS, and RPE layer thicknesses were less in the nasal and temporal macula. Relative sparing of the ONL+ and/or OS layers was detected in the nasal (i.e., peripapillary) macula in 8 of 13 patients with extramacular disease on FAF; relative functional sparing was also detected in this subgroup. All 14 patients with disease confined to the central macula, as detected on FAF, showed ONL+ and OS layer thinning in regions of normal RPE thickness.
conclusionsRelative peripapillary sparing was detected in STGD1 patients with extramacular disease on FAF. Photoreceptor thinning may precede RPE degeneration in STGD1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.