ArticleDiabetes2011
Obesity-associated hepatosteatosis and impairment of glucose homeostasis are attenuated by haptoglobin deficiency.
Article in Diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
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- SARS-CoV-2 Infection Alters the Phenotype and Gene Expression of Adipocytes.International journal of molecular sciences · 2024Article
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- Relationship among Body Composition, Adipocytokines, and Irisin on Exercise Capacity and Quality of Life in COPD: A Pilot Study.Biomolecules · 2022Article
- Progress on haptoglobin and metabolic diseases.World journal of diabetes · 2021Review
- ICH3, a selective alpha7 nicotinic acetylcholine receptor agonist, modulates adipocyte inflammation associated with obesity.Journal of endocrinological investigation · 2020Article
- Haptoglobin Phenotypes Are Associated with the Postload Glucose and Insulin Levels in Pediatric Obesity.International journal of endocrinology · 2020Article
- Human haptoglobin contributes to breast cancer oncogenesis through glycolytic activity modulation.American journal of cancer research · 2020Article
- Sick fat: the good and the bad of old and new circulating markers of adipose tissue inflammation.Journal of endocrinological investigation · 2019Review
- N-Terminal Acetylation and C-Terminal Amidation ofMarine drugs · 2019Article
- S100A4 protects mice from high-fat diet-induced obesity and inflammation.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Early Effects of a Low Fat, Fructose-Rich Diet on Liver Metabolism, Insulin Signaling, and Oxidative Stress in Young and Adult Rats.Frontiers in physiology · 2018Article
- Circulating Haptoglobin and Metabolic Syndrome in Renal Transplant Recipients.Scientific reports · 2017Article
- High Fat Diet and Inflammation - Modulation of Haptoglobin Level in Rat Brain.Frontiers in cellular neuroscience · 2015Article
- Dynamic and extensive metabolic state-dependent regulation of cytokine expression and circulating levels.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Article
- Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats.American journal of physiology. Renal physiology · 2013Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveHaptoglobin (Hp) is upregulated in both inflammation and obesity. The low chronic inflammatory state, caused by massive adipose tissue macrophage (ATM) infiltration found in obesity, and low adiponectin have been implicated in the development of insulin resistance and hepatosteatosis. The aim of this work was to investigate whether and how Hp interferes with the onset of obesity-associated complications. RESEARCH DESIGN AND
methodsHp-null (Hp(-/-)) and wild-type (WT) mice were metabolically profiled under chow-food diet (CFD) and high-fat diet (HFD) feeding by assessing physical parameters, glucose tolerance, insulin sensitivity, insulin response to glucose load, liver triglyceride content, plasma levels of leptin, insulin, glucose, and adiponectin. ATM content was evaluated by using immunohistochemistry (anti-F4/80 antibody). Adiponectin expression was measured in Hp-treated, cultured 3T3-L1 and human adipocytes.
resultsNo genotype-related difference was found in CFD animals. HFD-Hp(-/-) mice revealed significantly higher glucose tolerance, insulin sensitivity, glucose-stimulated insulin secretion, and adiponectin expression and reduced hepatomegaly/steatosis compared with HFD-WT mice. White adipose tissue (WAT) of HFD-Hp(-/-) mice showed higher activation of insulin signaling cascade, lower ATM, and higher adiponectin expression. Hp was able to inhibit adiponectin expression in cultured adipocytes.
conclusionsWe demonstrated that in the absence of Hp, obesity-associated insulin resistance and hepatosteatosis are attenuated, which is associated with reduced ATM content, increased plasma adiponectin, and higher WAT insulin sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.