ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Host immunity and pathogen strain contribute to intestinal disaccharidase impairment following gut infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
66 citing papers in PubMed, 116 citations in OpenAlex.
- Pathogenicity and virulence ofVirulence · 2026Review
- Bile acid sequestration reveals microbiome remodeling that dominates FXR signaling to shape host responses to enteric infection.PLoS pathogens · 2026Article
- Analysis ofInfection and immunity · 2026Article
- Disaccharidase testing and clinical outcomes: a retrospective study.Proceedings (Baylor University. Medical Center) · 2026Article
- High efficacy of camphene and metronidazole combination therapy againstParasite epidemiology and control · 2025Article
- Giardia-induced Type 2 mucosal immunity attenuates intestinal inflammation caused by co-infection or colitis in mice.Nature microbiology · 2025Article
- Dietary Glyceryl Polyethylene Glycol Ricinoleate as an Additive to Improve Intestinal Health in Post-Weaning Piglets.Animals : an open access journal from MDPI · 2025Article
- Enzymatic Regulation of the Gut Microbiota: Mechanisms and Implications for Host Health.Biomolecules · 2024Review
- The pathogenic responses elicited during exposure of human intestinal cell line with Giardia duodenalis excretory-secretory products and the potential attributed endocytosis mechanism.Medical microbiology and immunology · 2024Article
- Article
- 12-Hydroxyeicosatetraenoic acid is the only enzymatically produced HETE increased under brain ischemia.Prostaglandins, leukotrienes, and essential fatty acids · 2024Article
- Gut microbiome and NAFLD: impact and therapeutic potential.Frontiers in microbiology · 2024Review
- A shotgun metagenomic analysis of the fecal microbiome in humans infected with Giardia duodenalis.Parasites & vectors · 2023Article
- Giardia hinders growth by disrupting nutrient metabolism independent of inflammatory enteropathy.Nature communications · 2023Article
- Review
- Synergistic Effect of Polysaccharides from Chamomile Tea with Nitazoxanide Increases Treatment Efficacy againstLife (Basel, Switzerland) · 2022Article
- Immune Impairment Associated with Vitamin A Deficiency: Insights from Clinical Studies and Animal Model Research.Nutrients · 2022Review
- Conserved metabolic enzymes as vaccine antigens for giardiasis.PLoS neglected tropical diseases · 2022Article
- Role of milk carbohydrates in intestinal health of nursery pigs: a review.Journal of animal science and biotechnology · 2022Review
- Giardial lipid rafts share virulence factors with secreted vesicles and participate in parasitic infection in mice.Frontiers in cellular and infection microbiology · 2022Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Infection or other inflammatory insults in the small intestine often result in reduced disaccharidase enzyme levels. Using a mouse model of giardiasis, we examined the role of host immunity and pathogen virulence in mediating disaccharidase deficiency postinfection (p.i.). C57BL/6J mice were infected with two strains, WB and GS, of the human parasite Giardia duodenalis. The levels of sucrase, maltase, and lactase decreased in wild-type mice p.i. with the GS strain but not with the WB strain. Both CD4-deficient and SCID mice failed to eliminate the infection and did not exhibit disaccharidase deficiency. β(2)-Microglobulin knockout animals controlled infections similar to wild-type mice but exhibited no decrease in disaccharidase activity. Analysis of cytokine production by spleen and mesenteric lymph node cells showed production of IL-4, IL-10, IL-13, IL-17, IL-22, TNF-α, and IFN-γ p.i. with both WB and GS, with IFN-γ being the dominant cytokine for both parasite strains. Mesenteric lymph node cells produced lower levels of cytokines compared with splenocytes in response to parasite extract, although the overall pattern was similar. These data suggest that T cell responses mediate parasite clearance whereas also contributing to pathogenesis. They also demonstrate that differences in pathogen strain can also determine the outcome of infection and further our understanding of the clinical variation seen in human giardiasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.