ArticleApplied and environmental microbiology2011
Anatoxin-a synthetase gene cluster of the cyanobacterium Anabaena sp. strain 37 and molecular methods to detect potential producers.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed, 216 citations in OpenAlex.
- Genomic insights into the taxonomy, safety and biotechnological potential ofMicrobial genomics · 2026Article
- Investigation of cyanobacteria-hosted antibiotic resistance genes in cyanoHAB-impacted drinking water sources.Environmental science and pollution research international · 2026Article
- Anabaena-a promising chassis for space exploration.NPJ microgravity · 2026Review
- Unanticipated similarities and expected differences in the taxonomic composition and potential toxicity of cyanobacteria in biological soil crusts across hot and cold deserts.Frontiers in microbiology · 2026Article
- Comprehensive Study of Some Cyanobacteria in Moscow Waterbodies (Russia), Including Characteristics of the ToxigenicToxins · 2025Article
- Diel and spatial variability in cyanobacterial composition, gene abundance, and toxin concentration: a pilot study.Scientific reports · 2025Article
- Unveiling the Biotechnological Potential of Cyanobacteria from the Portuguese LEGE-CC Collection Through Lipidomics and Antioxidant and Lipid-Lowering Properties.Molecules (Basel, Switzerland) · 2025Article
- Growth and anatoxin-a production of Microcoleus (Cyanobacteria) strains from streams in California, USA.Harmful algae · 2025Article
- Taxonomic and functional metagenomic assessment of a Dolichospermum bloom in a large and deep lake south of the Alps.FEMS microbiology ecology · 2024Article
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- Cyanobacterial Harmful Algal Mats (CyanoHAMs) in tropical rivers of central Mexico and their potential risks through toxin production.Environmental monitoring and assessment · 2024Article
- Transdisciplinary approaches for the study of cyanobacteria and cyanotoxins.Current research in microbial sciences · 2024Article
- First Polyphasic Study of Cheffia Reservoir (Algeria) Cyanobacteria Isolates Reveals Toxic Picocyanobacteria Genotype.Microorganisms · 2023Article
- Cyanotoxins, biosynthetic gene clusters, and factors modulating cyanotoxin biosynthesis.World journal of microbiology & biotechnology · 2023Review
- Cyanobacteria and Their Metabolites in Mono- and Polidominant Shallow Eutrophic Temperate Lakes.International journal of environmental research and public health · 2022Article
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- Beyond Soil-Dwelling Actinobacteria: Fantastic Antibiotics and Where to Find Them.Antibiotics (Basel, Switzerland) · 2022Review
- Nitrogen and phosphorus significantly alter growth, nitrogen fixation, anatoxin-a content, and the transcriptome of the bloom-forming cyanobacterium,Frontiers in microbiology · 2022Article
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Authors and funding
9 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyanobacterial mass occurrences are common in fresh and brackish waters. They pose a threat to water users due to toxins frequently produced by the cyanobacterial species present. Anatoxin-a and homoanatoxin-a are neurotoxins synthesized by various cyanobacteria, e.g., Anabaena, Oscillatoria, and Aphanizomenon. The biosynthesis of these toxins and the genes involved in anatoxin production were recently described for Oscillatoria sp. strain PCC 6506 (A. Méjean et al., J. Am. Chem. Soc. 131:7512-7513, 2009). In this study, we identified the anatoxin synthetase gene cluster (anaA to anaG and orf1; 29 kb) in Anabaena sp. strain 37. The gene (81.6% to 89.2%) and amino acid (78.8% to 86.9%) sequences were highly similar to those of Oscillatoria sp. PCC 6506, while the organization of the genes differed. Molecular detection methods for potential anatoxin-a and homoanatoxin-a producers of the genera Anabaena, Aphanizomenon, and Oscillatoria were developed by designing primers to recognize the anaC gene. Anabaena and Oscillatoria anaC genes were specifically identified in several cyanobacterial strains by PCR. Restriction fragment length polymorphism (RFLP) analysis of the anaC amplicons enabled simultaneous identification of three producer genera: Anabaena, Oscillatoria, and Aphanizomenon. The molecular methods developed in this study revealed the presence of both Anabaena and Oscillatoria as potential anatoxin producers in Finnish fresh waters and the Baltic Sea; they could be applied for surveys of these neurotoxin producers in other aquatic environments.
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