Evidence map›Paper›PMID 21873426›Full record

ReviewThe Journal of biological chemistry2011

Termination of protein synthesis in mammalian mitochondria.

Zofia M A Chrzanowska-Lightowlers, Aleksandra Pajak, Robert N Lightowlers

Abstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Mitochondrial ribosomes in cancer.Seminars in cancer biology · 2017
    Review
  8. Article
  9. Review
  10. Review
  11. Protein biosynthesis in mitochondria.Biochemistry. Biokhimiia · 2013
    Review
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zofia M A Chrzanowska-LightowlersMitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom.
Aleksandra Pajak
Robert N Lightowlers

Funding

Biotechnology and Biological Sciences Research Council BB/F011520/1
6 · The paper itself

Abstract

All mechanisms of protein synthesis can be considered in four stages: initiation, elongation, termination, and ribosome recycling. Remarkable progress has been made in understanding how these processes are mediated in the cytosol of many species; however, details of organellar protein synthesis remain sketchy. This is an important omission, as defects in human mitochondrial translation are known to cause disease and may contribute to the aging process itself. In this minireview, we focus on the recent advances that have been made in understanding how one of these processes, translation termination, occurs in the human mitochondrion.

Indexed as

Protein BiosynthesisAnimalsBacterial ProteinsCodonCodon, TerminatorComputational BiologyFungal ProteinsGene Expression RegulationHumansMitochondriaModels, BiologicalModels, GeneticOpen Reading FramesRibosomesRNA, MessengerBacterial ProteinsCodonCodon, TerminatorFungal ProteinsRNA, Messenger

Identifiers

PMID21873426
PMCPMC3186377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.