ArticleToxicological sciences : an official journal of the Society of Toxicology2011
Effects of developmental exposure to polychlorinated biphenyls and/or polybrominated diphenyl ethers on cochlear function.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Effects of polychlorinated biphenyls on the peripheral and central auditory systems.Hearing research · 2025Review
- 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) induces early hearing loss in guinea pigs via activating AhR to trigger mitochondrial and endoplasmic reticulum stress-regulated autophagy.Archives of toxicology · 2025Article
- Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food.EFSA journal. European Food Safety Authority · 2024Article
- Retinol and Pro-Vitamin A Carotenoid Nutritional Status during Pregnancy Is Associated with Newborn Hearing Screen Results.Nutrients · 2023Article
- Windows of sensitivity to toxic chemicals in the development of the endocrine system: an analysis of ATSDR's toxicological profile database.International journal of environmental health research · 2022Review
- The Future of Neurotoxicology: A Neuroelectrophysiological Viewpoint.Frontiers in toxicology · 2021Article
- Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres.International journal of molecular sciences · 2020Article
- Gut Microbiota Modulates Interactions Between Polychlorinated Biphenyls and Bile Acid Homeostasis.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Cocaine sensitization in adult Long-Evans rats perinatally exposed to polychlorinated biphenyls.Neurotoxicology and teratology · 2017Article
- DPOAEs in infants developmentally exposed to PCBs show two differently time spaced exposure sensitive windows.Chemosphere · 2016Article
- Developmental exposure to PCBs alters the activation of the auditory cortex in response to GABANeurotoxicology · 2016Article
- Developmental PCB Exposure Increases Audiogenic Seizures and Decreases Glutamic Acid Decarboxylase in the Inferior Colliculus.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Prenatal low dosage dioxin (TCDD) exposure impairs cochlear function resulting in auditory neuropathy.Hearing research · 2016Article
- Environmental exposure to organochlorine pesticides and deficits in cochlear status in children.Environmental science and pollution research international · 2015Article
- Developmental PCB exposure increases susceptibility to audiogenic seizures in adulthood.Neurotoxicology · 2015Article
- The effect of the aquatic contaminants bisphenol-A and PCB-95 on the zebrafish lateral line.Neurotoxicology · 2015Article
- Prenatal and postnatal serum PCB concentrations and cochlear function in children at 45 months of age.Environmental health perspectives · 2014Article
- PCBs and impaired cochlear function in children: comparing pre- and postnatal exposures.Environmental health perspectives · 2014Article
- Early exposure to bisphenol A alters neuron and glia number in the rat prefrontal cortex of adult males, but not females.Neuroscience · 2014Article
- Making sense with thyroid hormone--the role of T(3) in auditory development.Nature reviews. Endocrinology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Developmental exposure to polychlorinated biphenyls (PCBs) causes hearing loss that may be due to reduced thyroxine during cochlear development. Polybrominated diphenyl ethers (PBDEs) are structurally similar to PCBs and reduce thyroxine. This study utilized an environmental PCB mixture and a commercial PBDE mixture, DE-71, that represents the PBDEs found in humans to assess the potential for additive effects of PCBs and PBDEs on cochlear function. Female Long-Evans rats were dosed with corn oil vehicle, PCBs (3 or 6 mg/kg), molar equivalent doses of PBDEs (5.7 or 11.4 mg/kg), 3 mg/kg PCBs + 5.7 mg/kg PBDEs, or 6 mg/kg PCBs + 11.4 mg/kg PBDEs throughout gestation and lactation. At weaning, pup blood was taken to assess thyroxine concentrations. One male and one female from each litter were maintained until adulthood for distortion product otoacoustic emission (DPOAE) measurements of cochlear function. DPOAE amplitudes were decreased and thresholds were elevated in the 6 mg/kg PCB group. Exposure to PBDEs did not cause DPOAE deficits. There was an interactive effect from combined exposure such that the individual low doses of PCBs and PBDEs did not result in DPOAE deficits, but the two combined produced a deficit similar to that in the high-dose PCB group. Serum thyroxine concentrations of all groups were reduced compared with controls, but PBDEs produced a less dramatic reduction than PCBs, which could explain the lack of DPOAE effects. Importantly, there was evidence that the co-exposure to subthreshold doses of PCBs and PBDEs can have an additive effect on cochlear function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.