ArticleProceedings of the National Academy of Sciences of the United States of America2011
Global impairment and therapeutic restoration of visual plasticity mechanisms after a localized cortical stroke.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Motor cortex rTMS modulates adult ocular dominance plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Article
- MMP2 and MMP9 Activity Is Crucial for Adult Visual Cortex Plasticity in Healthy and Stroke-Affected Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Lysophosphatidylcholines and phosphatidylcholines as biomarkers for stroke recovery.Frontiers in neurology · 2022Article
- Barrel cortex plasticity after photothrombotic stroke involves potentiating responses of pre-existing circuits but not functional remapping to new circuits.Nature communications · 2021Article
- Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models.Neural regeneration research · 2021Article
- The Delta-Subunit Selective GABAFrontiers in neuroscience · 2019Article
- Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression.Frontiers in psychiatry · 2019Review
- Diet-induced vitamin D deficiency has no effect on acute post-stroke outcomes in young male mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Article
- Peri-Operative Inflammatory Cytokines in Plasma of the Elderly Correlate in Prospective Study with Postoperative Changes in Cognitive Test Scores.International journal of anesthesiology & research · 2016Article
- Article
- Physical Exercise Preserves Adult Visual Plasticity in Mice and Restores it after a Stroke in the Somatosensory Cortex.Frontiers in aging neuroscience · 2016Article
- Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective.International journal of molecular sciences · 2015Review
- Article
- Epigenetic mechanisms of neuroplasticity and the implications for stroke recovery.Experimental neurology · 2015Review
- Article
- Environmental enrichment extends ocular dominance plasticity into adulthood and protects from stroke-induced impairments of plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Cortico-cortical interactions influence binocularity of the primary visual cortex of adult mice.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We tested the influence of a photothrombotic lesion in somatosensory cortex on plasticity in the mouse visual system and the efficacy of anti-inflammatory treatment to rescue compromised learning. To challenge plasticity mechanisms, we induced monocular deprivation (MD) in 3-mo-old mice. In control animals, MD induced an increase of visual acuity of the open eye and an ocular dominance (OD) shift towards this eye. In contrast, after photothrombosis, there was neither an enhancement of visual acuity nor an OD-shift. However, OD-plasticity was present in the hemisphere contralateral to the lesion. Anti-inflammatory treatment restored sensory learning but not OD-plasticity, as did a 2-wk delay between photothrombosis and MD. We conclude that (i) both sensory learning and cortical plasticity are compromised in the surround of a cortical lesion; (ii) transient inflammation is responsible for impaired sensory learning, suggesting anti-inflammatory treatment as a useful adjuvant therapy to support rehabilitation following stroke; and (iii) OD-plasticity cannot be conceptualized solely as a local process because nonlocal influences are more important than previously assumed.
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