ArticleProceedings of the National Academy of Sciences of the United States of America2011
CD4+ T cells from elite suppressors are more susceptible to HIV-1 but produce fewer virions than cells from chronic progressors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed, 42 citations in OpenAlex.
- Ex vivo HIV entry into blood CD4+ T cells does not predict heterosexual HIV acquisition in women.PloS one · 2018Trial
- HIV-1 infection does not confer intrinsic resistance to cell death induced by cytotoxic T lymphocytes.bioRxiv : the preprint server for biology · 2026Article
- Article
- Learning to Be Elite: Lessons From HIV-1 Controllers and Animal Models on Trained Innate Immunity and Virus Suppression.Frontiers in immunology · 2022Review
- CD8Frontiers in microbiology · 2021Article
- HIV-1 elite controllers: an immunovirological review and clinical perspectives.Journal of virus eradication · 2019Article
- Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro.PLoS pathogens · 2019Article
- Analysis ofJournal of virus eradication · 2018Article
- Mechanisms of Virologic Control and Clinical Characteristics of HIV+ Elite/Viremic Controllers.The Yale journal of biology and medicine · 2017Review
- Characterization of Elite Suppressors Cell-Associated HIV-1 mRNA at Baseline and with T Cell Activation .The Yale journal of biology and medicine · 2017Article
- Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers.Retrovirology · 2017Article
- Cytokines Elevated in HIV Elite Controllers Reduce HIV ReplicationJournal of virology · 2017Article
- Identification of miRNA-mRNA crosstalk in CD4Journal of translational medicine · 2017Article
- HIV-1 cellular and tissue replication patterns in infected humanized mice.Scientific reports · 2016Article
- HIV-1 Virion Production from Single Inducible Proviruses following T-Cell Activation Ex Vivo.Journal of virology · 2016Article
- Medroxyprogesterone acetate increases HIV-1 infection of unstimulated peripheral blood mononuclear cells in vitro.AIDS (London, England) · 2015Article
- Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers.Journal of virology · 2015Article
- Linking pig-tailed macaque major histocompatibility complex class I haplotypes and cytotoxic T lymphocyte escape mutations in simian immunodeficiency virus infection.Journal of virology · 2014Article
- Article
- Expression profile of host restriction factors in HIV-1 elite controllers.Retrovirology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Elite suppressors/controllers (ES) are HIV-1-infected individuals who maintain stable CD4(+) T-cell counts and viral loads of <50 copies/mL without antiretroviral therapy. Research has predominantly focused on immune factors contributing to the control of viral replication in these patients. A more fundamental question, however, is whether there are differences in the nature of CD4(+) T-cell infection in ES compared with viremic patients. Here, we compare chronic progressor (CP), ES, and uninfected donors in terms of three aspects of CD4(+) T-cell infection: cellular susceptibility to infection, death of infected cells, and production of virus from infected cells. Using multiple methods of infection and both single-cycle and replication-competent virus, we show that unmanipulated CD4(+) T-cell populations from ES are actually more susceptible to HIV-1 infection than those populations from CP. Depletion of highly susceptible cells in CP may contribute to this difference. Using 7AAD and AnnexinV staining, we show that infected cells die more rapidly than uninfected cells, but the increased death of infected cells from CP and ES is proportional. Finally, using an assay for measuring virus production, we show that virus production by cells from CP is high compared with virus production by cells from ES or uninfected donors. This higher virus production is linked to cellular activation levels. These data identify fundamental differences in chronic infection of ES and CP that likely contribute to differential HIV-1 disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.