ArticleProceedings of the National Academy of Sciences of the United States of America2011
Multilevel autoregulation of λ repressor protein CI by DNA looping in vitro.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 49 citations in OpenAlex.
- Engineering oncolytic bacteria as precision cancer therapeutics: design principles, therapeutic strategies, and translational perspectives.Protein & cell · 2026Review
- Characterization of the novel Cutibacterium acnes phage KIT08 and its associated pseudolysogenic bacterial isolate.Archives of microbiology · 2025Article
- Insights on the regulation and function of the CRISPR/Cas transposition system located in the pathogenicity island VpaI-7 fromInfection and immunity · 2025Article
- Research on phage λ: a lucky choice.EcoSal Plus · 2024Review
- Deciphering the Genetic Architecture ofViruses · 2024Article
- Insights into Superinfection Immunity Regulation of Xanthomonas axonopodis Filamentous Bacteriophage cf.Current microbiology · 2023Article
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- Control of λ LysogenicACS synthetic biology · 2022Article
- RNA polymerase efficiently transcribes through DNA-scaffolded, cooperative bacteriophage repressor complexes.FEBS letters · 2022Article
- Ultrasound-controllable engineered bacteria for cancer immunotherapy.Nature communications · 2022Article
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- The Developmental Switch in Bacteriophage λ: A Critical Role of the Cro Protein.Journal of molecular biology · 2018Article
- Expanding the toolbox forSynthetic biology (Oxford, England) · 2018Article
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- Engineering orthogonal dual transcription factors for multi-input synthetic promoters.Nature communications · 2016Article
- Aspects of protein-DNA interactions: a review of quantitative thermodynamic theory for modelling synthetic circuits utilising LacI and CI repressors, IPTG and the reporter gene lacZ.Biophysical reviews · 2016Review
- New Insights into the Phage Genetic Switch: Effects of Bacteriophage Lambda Operator Mutations on DNA Looping and Regulation of PJournal of molecular biology · 2016Article
- Supercoiling biases the formation of loops involved in gene regulation.Biophysical reviews · 2016Review
- Measurement of gene regulation in individual cells reveals rapid switching between promoter states.Science (New York, N.Y.) · 2016Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
The prophage state of bacteriophage λ is extremely stable and is maintained by a highly regulated level of λ repressor protein, CI, which represses lytic functions. CI regulates its own synthesis in a lysogen by activating and repressing its promoter, P(RM). CI participates in long-range interactions involving two regions of widely separated operator sites by generating a loop in the intervening DNA. We investigated the roles of each individual site under conditions that permitted DNA loop formation by using in vitro transcription assays for the first time on supercoiled DNA that mimics in vivo situation. We confirmed that DNA loops generated by oligomerization of CI bound to its operators influence the autoactivation and autorepression of P(RM) regulation. We additionally report that different configurations of DNA loops are central to this regulation--one configuration further enhances autoactivation and another is essential for autorepression of P(RM).
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