ArticleComputers in biology and medicine2011
Simulating ventilation distribution in heterogenous lung injury using a binary tree data structure.
Article in Computers in biology and medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Quantitative assessment of lung mechanical properties in ARDS using X-ray computed tomography.Intensive care medicine experimental · 2026Review
- Simulation of Central Airway Gas Flow Dynamics During Conventional and Multifrequency Ventilation.Journal of biomechanical engineering · 2025Article
- Design and Implementation of a Computer-Controlled Hybrid Oscillatory Ventilator.Journal of medical devices · 2025Article
- Forward Computational Modeling of Respiratory Airflow.Applied sciences (Basel, Switzerland) · 2024Article
- Assessment of Heterogeneity in Lung Structure and Function During Mechanical Ventilation: A Review of Methodologies.Journal of engineering and science in medical diagnostics and therapy · 2022Review
- Translational Role of Rodent Models to Study Ventilator-Induced Lung Injury.Translational perioperative and pain medicine · 2021Article
- Oscillatory ventilation redux: alternative perspectives on ventilator-induced lung injury in the acute respiratory distress syndrome.Current opinion in physiology · 2021Review
- High-Frequency Oscillatory Ventilation and Ventilator-Induced Lung Injury: Size Does Matter.Critical care medicine · 2020Article
- Reactance and elastance as measures of small airways response to bronchodilator in asthma.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Strain, strain rate, and mechanical power: An optimization comparison for oscillatory ventilation.International journal for numerical methods in biomedical engineering · 2019Article
- Computational Modeling of Primary Blast Lung Injury: Implications for Ventilator Management.Military medicine · 2019Article
- Parenchymal strain heterogeneity during oscillatory ventilation: why two frequencies are better than one.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Intratidal Overdistention and Derecruitment in the Injured Lung: A Simulation Study.IEEE transactions on bio-medical engineering · 2017Article
- Regional gas transport in the heterogeneous lung during oscillatory ventilation.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Multifrequency Oscillatory Ventilation in the Premature Lung: Effects on Gas Exchange, Mechanics, and Ventilation Distribution.Anesthesiology · 2015Article
- Effects of airway tree asymmetry on the emergence and spatial persistence of ventilation defects.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Impact of ventilation frequency and parenchymal stiffness on flow and pressure distribution in a canine lung model.Annals of biomedical engineering · 2013Article
- What can computed tomography and magnetic resonance imaging tell us about ventilation?Journal of applied physiology (Bethesda, Md. : 1985) · 2012Review
- Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
To determine the impact of mechanical heterogeneity on the distribution of regional flows and pressures in the injured lung, we developed an anatomic model of the canine lung comprised of an asymmetric branching airway network, which can be stored as binary tree data structure. The entire tree can be traversed using a recursive flow divider algorithm, allowing for efficient computation of acinar flow and pressure distributions in a mechanically heterogeneous lung. These distributions were found to be highly dependent on ventilation frequency and the heterogeneity of tissue elastances, reflecting the preferential distribution of ventilation to areas of lower regional impedance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.