ArticleSchizophrenia research2011
Proton magnetic resonance spectroscopy and thought disorder in childhood schizophrenia.
Article in Schizophrenia research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Imaging-based neurochemistry in schizophrenia: a systematic review and implications for dysfunctional long-term potentiation.Schizophrenia bulletin · 2015Pooled it
- Glutamate in Pediatric Obsessive-Compulsive Disorder and Response to Cognitive-Behavioral Therapy: Randomized Clinical Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Trial
- Glutamatergic hypo-function in the left superior and middle temporal gyri in early schizophrenia: a data-driven three-dimensional proton spectroscopic imaging study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Article
- Differential neuroimaging indices in prefrontal white matter in prenatal alcohol-associated ADHD versus idiopathic ADHD.Birth defects research · 2019Article
- Investigation of Heschl's gyrus and planum temporale in patients with schizophrenia and bipolar disorder: a proton magnetic resonance spectroscopy study.Schizophrenia research · 2015Article
- Glutamatergic neurometabolites during early abstinence from chronic methamphetamine abuse.The international journal of neuropsychopharmacology · 2014Article
- Thalamic glutamate decreases with cigarette smoking.Psychopharmacology · 2014Article
- Glutamatergic abnormalities in schizophrenia: a review of proton MRS findings.Schizophrenia research · 2014Review
- Imaging glutamate in schizophrenia: review of findings and implications for drug discovery.Molecular psychiatry · 2014Review
- Glutamate levels in the associative striatum before and after 4 weeks of antipsychotic treatment in first-episode psychosis: a longitudinal proton magnetic resonance spectroscopy study.JAMA psychiatry · 2013Article
- Metabolomic imaging of prostate cancer with magnetic resonance spectroscopy and mass spectrometry.European journal of nuclear medicine and molecular imaging · 2013Review
- Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive-compulsive disorder.Journal of psychiatric research · 2013Article
- 1H MRSI of middle frontal gyrus in pediatric ADHD.Journal of psychiatric research · 2013Article
- MRSI correlates of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAlthough magnetic resonance spectroscopy has identified metabolic abnormalities in adult and childhood schizophrenia, no prior studies have investigated the relationship between neurometabolites and thought disorder. This study examined this association in language-related brain regions using proton magnetic resonance spectroscopic imaging ((1)H MRSI).
methodMRSI was acquired bilaterally from 28 youth with childhood-onset schizophrenia and 34 healthy control subjects in inferior frontal, middle frontal, and superior temporal gyri at 1.5T and short echo time (TR/TE = 1500/30 ms). CSF-corrected "total NAA" (tNAA; N-acetyl-aspartate + N-acetyl-aspartyl-glutamate), glutamate + glutamine (Glx), creatine + phosphocreatine (Cr + PCr), choline compounds (Cho), and myo-inositol (mI) were assayed in manually drawn regions-of-interest partitioned into gray matter, white matter, and CSF and then coregistered with MRSI. Speech samples of all subjects were coded for thought disorder.
resultsIn the schizophrenia group, the severity of formal thought disorder correlated significantly with tNAA in the left inferior frontal and superior temporal gyri and with Cr + PCr in left superior temporal gyrus.
conclusionsNeurometabolite concentrations in language-related brain regions are associated with thought disorder in childhood-onset schizophrenia.
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Registered trials
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