Evidence map›Paper›PMID 21872346›Full record

ArticleJournal of neuroimmunology2011

Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis.

Kathryn M Brennan, Francesc Galban-Horcajo, Simon Rinaldi, Colin P O'Leary, Carl S Goodyear, Gabriela Kalna, Ariel Arthur, Christina Elliot, Sue Barnett, Christopher Linington and 3 more

Abstract read
In one paragraph

Article in Journal of neuroimmunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. The brainstem connectome database.Scientific data · 2022
    Article
  10. Review
  11. Review
  12. Inflammation in multiple sclerosis.Therapeutic advances in neurological disorders · 2021
    Review
  13. Article
  14. Review
  15. Serum antibodies to phosphatidylcholine in MS.Neurology(R) neuroimmunology & neuroinflammation · 2020
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Kathryn M BrennanInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, G12 8TA, UK.
Francesc Galban-Horcajo
Simon Rinaldi
Colin P O'Leary
Carl S Goodyear
Gabriela Kalna
Ariel Arthur
Christina Elliot
Sue Barnett
Christopher Linington
Jeffrey L Bennett
Gregory P Owens
Hugh J Willison
University of Glasgow · GBSouthern General Hospital · GBUniversity of Colorado Denver · US

Funding

Varicella Zoster Virus Latency in Human GangliaP01NS032623 · NINDS · UNIVERSITY OF COLORADO DENVER · PI MAHLAINGAM, RAVI · 1993 to 2008
$12.3M
The Role of Intrathecal Plasma Cell Clones in MS PathogenesisR01NS072141 · NINDS · UNIVERSITY OF COLORADO DENVER · PI OWENS, GREGORY PARKS · 2011 to 2015
$1.3M
NINDS NIH HHS P01 NS032623NINDS NIH HHS P01-NS32623-19NINDS NIH HHS R01 NS072141Wellcome TrustWellcome Trust 077041/Z/05/Z
6 · The paper itself

Abstract

The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma since its first description over forty years ago. We now report that the use of lipid arrays identifies heteromeric complexes of myelin derived lipids as a prominent target for this intrathecal B cell response.

Indexed as

Lipid MetabolismMultiple SclerosisAnalysis of VarianceAnimalsB-LymphocytesCells, CulturedEmbryo, MammalianHumansImmunoglobulin GMyelin Basic ProteinMyelin SheathO AntigensOligoclonal BandsRatsRats, Sprague-DawleySpinal CordImmunoglobulin GMyelin Basic ProteinO AntigensOligoclonal Bands

Identifiers

PMID21872346
PMCPMC3400538
OpenAlexW1968501869

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.