ArticleBiomaterials2011
The influence of elasticity and surface roughness on myogenic and osteogenic-differentiation of cells on silk-elastin biomaterials.
Article in Biomaterials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
62 citing papers in PubMed.
- Review
- Structuring the Future of Cultured Meat: Hybrid Gel-Based Scaffolds for Edibility and Functionality.Gels (Basel, Switzerland) · 2025Review
- Micropatterned Styrene-Butadiene-Styrene Thin Films Doped with Barium Titanate Nanoparticles: Effects on Myoblast Differentiation.ACS biomaterials science & engineering · 2025Article
- Innovative Processing and Sterilization Techniques to Unlock the Potential of Silk Sericin for Biomedical Applications.Gels (Basel, Switzerland) · 2025Article
- Skeletal muscle injury treatment using the Silk Elastin® injection in a rat model.Regenerative therapy · 2024Article
- Elastic fibers define embryonic tissue stiffness to enable buckling morphogenesis of the small intestine.Biomaterials · 2023Article
- Fine-Tuning Regulation of Surface Mobility by Acrylate Copolymers and Its Effect on Cell Adhesion and Differentiation.ACS applied bio materials · 2023Article
- Hydrogel viscoelasticity modulates migration and fusion of mesenchymal stem cell spheroids.Bioengineering & translational medicine · 2023Article
- Effect of the uronic acid composition of alginate in alginate/collagen hybrid hydrogel on chondrocyte behavior.Frontiers in bioengineering and biotechnology · 2023Article
- Viscoelastic Biomaterials for Tissue Regeneration.Tissue engineering. Part C, Methods · 2022Review
- Changes in Elastic Moduli of Fibrin Hydrogels Within the Myogenic Range Alter Behavior of Murine C2C12 and Human C25 Myoblasts Differently.Frontiers in bioengineering and biotechnology · 2022Article
- Influence of Cellular Microenvironment on Human Articular Chondrocyte Cell Signaling.Cartilage · 2021Article
- Recent advances in 3D bioprinting of musculoskeletal tissues.Biofabrication · 2021Review
- The molecular conformation of silk fibroin regulates osteogenic cell behavior by modulating the stability of the adsorbed protein-material interface.Bone research · 2021Article
- Natural-Based Hydrogels for Tissue Engineering Applications.Molecules (Basel, Switzerland) · 2020Review
- A novel lamellar structural biomaterial and its effect on bone regeneration.RSC advances · 2020Article
- Bioactive biodegradable polycitrate nanoclusters enhances the myoblast differentiation andBioactive materials · 2020Article
- Polydopamine and collagen coated micro-grated polydimethylsiloxane for human mesenchymal stem cell culture.Bioactive materials · 2019Article
- Soluble matrix protein is a potent modulator of mesenchymal stem cell performance.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Enhanced osteoinduction of electrospun scaffolds with assemblies of hematite nanoparticles as a bioactive interface.International journal of nanomedicine · 2019Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The interactions of C2C12 myoblasts and human bone marrow stem cells (hMSCs) with silk-tropoelastin biomaterials, and the capacity of each to promote attachment, proliferation, and either myogenic- or osteogenic-differentiation were investigated. Temperature-controlled water vapor annealing was used to control beta-sheet crystal formation to generate insoluble silk-tropoelastin biomaterial matrices at defined ratios of the two proteins. These ratios controlled surface roughness and micro/nano-scale topological patterns, and elastic modulus, stiffness, yield stress, and tensile strength. A combination of low surface roughness and high stiffness in the silk-tropoelastin materials promoted proliferation and myogenic-differentiation of C2C12 cells. In contrast, high surface roughness with micro/nano-scale surface patterns was favored by hMSCs. Increasing the content of human tropoelastin in the silk-tropoelastin materials enhanced the proliferation and osteogenic-differentiation of hMSCs. We conclude that the silk-tropoelastin composition facilitates fine tuning of the growth and differentiation of these cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.