ArticleProceedings of the National Academy of Sciences of the United States of America1990
Asymmetric distribution of dystrophin in developing and adult Torpedo marmorata electrocyte: evidence for its association with the acetylcholine receptor-rich membrane.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 58 citations in OpenAlex.
- Transcription of MyoD and myogenin in the non-contractile electrogenic cells of the weakly electric fish, Sternopygus macrurus.Development genes and evolution · 2004Article
- Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum.Molecular biology of the cell · 2003Article
- Actin interaction with purified dystrophin from electric organ of Torpedo marmorata: possible resemblance with filamin-actin interface.Journal of muscle research and cell motility · 1995Article
- Localization of dystrophin gene transcripts during mouse embryogenesis.The Journal of cell biology · 1992Article
- Evolutionary conservation of the dystrophin central rod domain.The Biochemical journal · 1992Article
- Immunocytochemical study of dystrophin in cultured mouse muscle cells by the quick-freezing and deep-etching method.The Histochemical journal · 1992Article
- Dystrophin and a dystrophin-related protein in intrafusal muscle fibers, and neuromuscular and myotendinous junctions.Acta neuropathologica · 1992Article
- Nicotinic receptor-associated 43K protein and progressive stabilization of the postsynaptic membrane.Molecular neurobiology · 1992Review
- Dystrophin is a component of the subsynaptic membrane.The Journal of cell biology · 1991Article
- The submembrane machinery for nicotinic acetylcholine receptor clustering.The Journal of cell biology · 1991Review
- Localization of dystrophin relative to acetylcholine receptor domains in electric tissue and adult and cultured skeletal muscle.The Journal of cell biology · 1991Article
- Increased acetylcholine sensitivity in Duchenne muscular dystrophy myotubes.Italian journal of neurological sciences · 1991Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dystrophin has been shown to occur in Torpedo electrocyte [Chang, H. W., Bock, E. & Bonilla, E. (1989) J. Biol. Chem. 264, 20831-20834], a highly polarized syncytium that is embryologically derived from skeletal muscle and displays functionally distinct plasma membrane domains on its innervated and noninnervated faces. In the present study, we investigated the subcellular distribution of dystrophin in the adult electrocyte from Torpedo marmorata and the evolution of its distribution during embryogenesis. Immunofluorescence experiments performed on adult electrocytes with a polyclonal antibody directed against chicken dystrophin revealed that dystrophin immunoreactivity codistributed exclusively with the acetylcholine receptor along the innervated membrane. At the ultrastructural level, dystrophin immunoreactivity appears confined to the face of the subsynaptic membrane exposed to the cytoplasm. In developing electrocytes (45-mm embryo), dystrophin is already detectable at the acetylcholine receptor-rich ventral pole of the cells before the entry of the electromotor axons. Furthermore, we show that dystrophin represents a major component of purified membrane fractions rich in acetylcholine receptor. A putative role of dystrophin in the organization and stabilization of the subsynaptic membrane domain of the electrocyte is discussed.
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