SynthesisAmerican journal of human genetics2011
A variant in MCF2L is associated with osteoarthritis.
Synthesis in American journal of human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 7 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.Nature genetics · 2018Pooled it
- Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry.Human molecular genetics · 2016Pooled it
- Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis.Annals of the rheumatic diseases · 2015Pooled it
- A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.Annals of the rheumatic diseases · 2014Pooled it
- Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.Nature genetics · 2014Pooled it
- Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies.Arthritis & rheumatology (Hoboken, N.J.) · 2014Pooled it
- Pooled it
- Genetic markers for knee osteoarthritis presence are not associated with disease progression - data from the IMI-APPROACH cohort.PloS one · 2025Article
- Comparative Analysis of Osteoarthritis Therapeutics: A Justification for Harnessing Retrospective Strategies via an Inverted Pyramid Model Approach.Biomedicines · 2024Review
- Unraveling epigenomic signatures and effectiveness of electroconvulsive therapy in treatment-resistant depression patients: a prospective longitudinal study.Clinical epigenetics · 2024Article
- The Genetic Markers of Knee Osteoarthritis in Women from Russia.Biomedicines · 2024Article
- Improved genetic prediction of the risk of knee osteoarthritis using the risk factor-based polygenic score.Arthritis research & therapy · 2023Article
- Integrin Subunit Alpha M, ITGAM Nonsynonymous SNP Is Associated with Knee Osteoarthritis among Thais: A Case-Control Study.Current issues in molecular biology · 2023Article
- Article
- Multi-omics molecular biomarkers and database of osteoarthritis.Database : the journal of biological databases and curation · 2022Article
- Genetics of osteoarthritis.Osteoarthritis and cartilage · 2022Review
- The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis.Calcified tissue international · 2021Review
- Article
- Identification of the key gene and pathways associated with osteoarthritis via single-cell RNA sequencing on synovial fibroblasts.Medicine · 2020Observational
- A novel variant near LSP1P3 is associated with knee osteoarthritis in the Chinese population.Clinical rheumatology · 2020Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors at 20 institutions in 4 countries.
Funding
Abstract
Osteoarthritis (OA) is a prevalent, heritable degenerative joint disease with a substantial public health impact. We used a 1000-Genomes-Project-based imputation in a genome-wide association scan for osteoarthritis (3177 OA cases and 4894 controls) to detect a previously unidentified risk locus. We discovered a small disease-associated set of variants on chromosome 13. Through large-scale replication, we establish a robust association with SNPs in MCF2L (rs11842874, combined odds ratio [95% confidence interval] 1.17 [1.11-1.23], p = 2.1 × 10(-8)) across a total of 19,041 OA cases and 24,504 controls of European descent. This risk locus represents the third established signal for OA overall. MCF2L regulates a nerve growth factor (NGF), and treatment with a humanized monoclonal antibody against NGF is associated with reduction in pain and improvement in function for knee OA patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.