ArticleExperimental gerontology2011
Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project.
Article in Experimental gerontology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Genetic associations with longevity in a Calabrian cohort: an exploratory genome-wide study.GeroScience · 2026Article
- Familial healthy aging and longevity: the role of spouses.BMC medicine · 2026Article
- Inflammaging and the sex-frailty paradox.Aging clinical and experimental research · 2025Article
- Lack of association between common polymorphisms associated with successful aging and longevity in the population of Sardinian Blue Zone.Scientific reports · 2024Article
- The Protective Effect of Familial Longevity Persists After Age 100: Findings From the Danish National Registers.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- End of Life Events and Causes of Death in Danish Long-Lived Siblings: Reduced Dementia Risk Compared to Sporadic Long-Livers.Journal of Alzheimer's disease : JAD · 2024Article
- Physical performance reference values for Japanese oldest old: a SONIC study.BMC geriatrics · 2022Article
- Physical resilience after a diagnosis of cardiovascular disease among offspring of long-lived siblings.European journal of ageing · 2022Article
- The 90 plus: longevity and COVID-19 survival.Molecular psychiatry · 2022Review
- Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover in the oldest females.Journal of translational medicine · 2021Article
- Omics in a Digital World: The Role of Bioinformatics in Providing New Insights Into Human Aging.Frontiers in genetics · 2021Review
- Physical robustness and resilience among long-lived female siblings: a comparison with sporadic long-livers.Aging · 2020Article
- Are Psycho-Behavioral Factors Accounting for Longevity?Frontiers in psychology · 2019Article
- Secondary phenotype analysis in ascertained family designs: application to the Leiden longevity study.Statistics in medicine · 2017Article
- Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.Annals of epidemiology · 2015Article
- Glomerular filtration rate in the elderly and in the oldest old: correlation with frailty and mortality.Age (Dordrecht, Netherlands) · 2014Article
- Article
- Health status and 6 years survival of 552 90+ Italian sib-ships recruited within the EU Project GEHA (GEnetics of Healthy Ageing).Age (Dordrecht, Netherlands) · 2014Article
- The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms.BioMed research international · 2014Review
- Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring.Age (Dordrecht, Netherlands) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
59 authors at 20 institutions in 12 countries.
Funding
Abstract
In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90 years or more together with one younger control person from 15 areas in 11 European countries through a coordinated and standardised effort. A biological sample, preferably a blood sample, was collected from each participant, and basic physical and cognitive measures were obtained together with information about health, life style, and family composition. From 2004 to 2008 a total of 2535 families comprising 5319 nonagenarian siblings were identified and included in the project. In addition, 2548 younger control persons aged 50-75 years were recruited. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control were formed and are available for genetic analyses (e.g. linkage studies and genome-wide association studies). Mortality follow-up improves the possibility of identifying families with the most extreme longevity phenotypes. With a mean follow-up time of 3.7 years the number of families with all participating siblings aged 95 years or more has increased by a factor of 5 to 750 families compared to when interviews were conducted. Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.