Evidence map›Paper›PMID 21871452›Full record

ReviewExperimental eye research2011

Molecular genetics in glaucoma.

Yutao Liu, R Rand Allingham

Abstract readReview
In one paragraph

Review in Experimental eye research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 3 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 3 syntheses or guidelines pooled it, 140 citations in OpenAlex.

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  9. New perspectives on DNA methylation modifications in ocular diseases.International journal of ophthalmology · 2025
    Review
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Yutao LiuCenter for Human Genetics, Duke University Medical Center, Durham, NC, USA.
R Rand Allingham
Duke Medical Center · USDuke University Hospital · US

Funding

Candidate Genes for Primary Open Angle GlaucomaR01EY013315 · NEI · DUKE UNIVERSITY · PI HAUSER, MICHAEL A · 2001 to 2011
$4.1M
Admixture Mapping of Glaucoma Genes in African AmericansR01EY019126 · NEI · DUKE UNIVERSITY · PI HAUSER, MICHAEL A · 2008 to 2012
$3.2M
NEI NIH HHS R01 EY013315NEI NIH HHS R01 EY019126
6 · The paper itself

Abstract

Glaucoma is a family of diseases whose pathology is defined by the progressive loss of retinal ganglion cells. Clinically, glaucoma presents as a distinctive optic neuropathy with associated visual field loss. Primary open-angle glaucoma (POAG), chronic angle-closure glaucoma (ACG), and exfoliation glaucoma (XFG) are the most prevalent forms of glaucoma globally and are the most common causes of glaucoma-related blindness worldwide. A host of genetic and environmental factors contribute to glaucoma phenotypes. This review examines the current status of genetic investigations of POAG, ACG, XFG, including the less common forms of glaucoma primary congenital glaucoma (PCG), the developmental glaucomas, and pigment dispersion glaucoma.

Indexed as

Exfoliation SyndromeGlaucoma, Angle-ClosureGlaucoma, Open-AngleHumansHydrophthalmosMolecular Biology

Identifiers

PMID21871452
PMCPMC4293633
OpenAlexW2032124492

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.