ArticleBMC cancer2011
Younger age as a prognostic indicator in breast cancer: a cohort study.
Article in BMC cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
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- Breast Cancer in Women Aged ≤35 Years: A Single-Center Retrospective Comparative Analysis by Age Subgroup.Diagnostics (Basel, Switzerland) · 2026Article
- Pathological characteristics and prognosis of very young patients with early breast cancer: a comparative analysis with older patients.Acta oncologica (Stockholm, Sweden) · 2026Article
- Epidemiological and clinical factors of breast cancer in a population of mostly Afro-descendant women.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- The impact of loco-regional treatment modality on the outcomes in breast cancer patients younger than forty years of age.BMC cancer · 2024Article
- Imaging Patterns in Breast Cancer for Women Under 40 Years: A Descriptive Cohort Study.Journal of epidemiology and global health · 2024Article
- Imaging Patterns in Breast Cancer for Women Under 40 Years: A Descriptive Cohort Study.Journal of epidemiology and global health · 2024Article
- What Is Known about Breast Cancer in Young Women?Cancers · 2023Review
- Incidence of breast cancer subtypes in immigrant and non-immigrant women in Norway.Breast cancer research : BCR · 2022Article
- Article
- Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients.Scientific reports · 2021Article
- Article
- Conditional Disease-Free and Overall Survival of 1,858 Young Women with Non-Metastatic Breast Cancer and with Participation in a Post-Therapeutic Rehab Programme according to Clinical Subtypes.Breast care (Basel, Switzerland) · 2021Article
- Clinicopathological characteristics and treatment of young women with breast cancer in China: a nationwide multicenter 10-year retrospective study.Gland surgery · 2021Article
- Correlation of the BI-RADS assessment categories of Papua New Guinean women with mammographic parenchymal patterns, age and diagnosis.Journal of medical radiation sciences · 2020Article
- Breast Cancer Incidence and Behavior in Younger Patients: A Study From the Surveillance, Epidemiology and End Results Database.World journal of oncology · 2020Article
- Should women with early breast cancer under 40 years of age have a routine 21-gene recurrence score testing: A SEER database study.Breast (Edinburgh, Scotland) · 2020Article
- Article
- Modelling excess mortality among breast cancer patients in the North East Region of Peninsular Malaysia, 2007-2011: a population-based study.BMC public health · 2019Article
- Mortality after breast cancer as a function of time since diagnosis by estrogen receptor status and age at diagnosis.International journal of cancer · 2019Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe debate continues as to whether younger women who present with breast cancer have a more aggressive form of disease and a worse prognosis. The objectives of this study were to determine the incidence of breast cancer in women under 40 years old and to analyse the clinicopathological characteristics and outcome compared to an older patient cohort.
methodsData was acquired from a review of charts and the prospectively reviewed GUH Department of Surgery database. Included in the study were 276 women diagnosed with breast cancer under the age of forty and 2869 women over forty. For survival analysis each women less than 40 was matched with two women over forty for both disease stage and grade.
resultsThe proportion of women diagnosed with breast cancer under the age of forty in our cohort was 8.8%. In comparison to their older counterparts, those under forty had a higher tumour grade (p = 0.044) and stage (p = 0.046), a lower incidence of lobular tumours (p < 0.001), higher estrogen receptor negativity (p < 0.001) and higher HER2 over-expression (p = 0.002); there was no statistical difference as regards tumour size (p = 0.477). There was no significant difference in overall survival (OS) for both groups; and factors like tumour size (p = 0.026), invasion (p = 0.026) and histological type (p = 0.027), PR (p = 0.031) and HER2 (p = 0.002) status and treatment received were independent predictors of OS
conclusionBreast cancer in younger women has distinct histopathological characteristics; however, this does not result in a reduced survival in this population.
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