ArticleParasites & vectors2011
Evaluation of Toxoplasma gondii as a live vaccine vector in susceptible and resistant hosts.
Article in Parasites & vectors, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- The Live-Attenuated PruΔAnimals : an open access journal from MDPI · 2026Article
- RecombinantFrontiers in immunology · 2026Article
- [Seroprevalence ofMedecine tropicale et sante internationale · 2025Article
- Live-attenuated PruΔgra72 strain of Toxoplasma gondii induces strong protective immunity against acute and chronic toxoplasmosis in mice.Parasites & vectors · 2024Article
- Revisiting the development of Trypanosoma rangeli in the vertebrate host.Memorias do Instituto Oswaldo Cruz · 2024Article
- A novel enemy of cancer: recent investigations into protozoan anti-tumor properties.Frontiers in cellular and infection microbiology · 2023Review
- Epidemiologic significance ofParasitology · 2020Review
- Investigating immune responses to parasites using transgenesis.Parasites & vectors · 2019Review
- Immuno-therapeutic potential of Schistosoma mansoni and Trichinella spiralis antigens in a murine model of colon cancer.Investigational new drugs · 2019Article
- Mutual interactions of the apicomplexan parasites Toxoplasma gondii and Eimeria tenella with cultured poultry macrophages.Parasites & vectors · 2018Article
- Experimental Toxoplasma gondii and Eimeria tenella co-infection in chickens.Parasitology research · 2017Article
- Seroprevalence ofThe Korean journal of parasitology · 2017Article
- Transfected Babesia bovis Expressing a Tick GST as a Live Vector Vaccine.PLoS neglected tropical diseases · 2016Article
- Transgenic Eimeria tenella as a vaccine vehicle: expressing TgSAG1 elicits protective immunity against Toxoplasma gondii infections in chickens and mice.Scientific reports · 2016Article
- Different applications of virus-like particles in biology and medicine: Vaccination and delivery systems.Biopolymers · 2016Review
- A Live Vector Expressing HPV16 L1 Generates an Adjuvant-Induced Antibody Response In-vivo.Iranian journal of cancer prevention · 2015Article
- Pathogenicity of Five Strains of Toxoplasma gondii from Different Animals to Chickens.The Korean journal of parasitology · 2015Article
- Ethanol and isopropanol trigger rapid egress of intracellular Eimeria tenella sporozoites.Parasitology research · 2015Article
- Interferon-Gamma Release Assay: An Effective Tool to Detect Early Toxoplasma gondii Infection in Mice.PloS one · 2015Article
- Compound DNA vaccine encoding SAG1/ SAG3 with A2/B subunit of cholera toxin as a genetic adjuvant protects BALB/c mice against Toxoplasma gondii.Parasites & vectors · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundToxoplasma gondii has been shown to trigger strong cellular immune responses to heterologous antigens expressed by the parasite in the inbred mouse model. We studied the immune response induced by T. gondii as an effective vaccine vector in chickens and rabbits.
resultsT. gondii RH strain was engineered to express the yellow fluorescent protein (YFP) in the cytoplasm. A subcutaneous injection of the transgenic T. gondii YFP in chickens afforded partial protection against the infection of transgenic E. tenella YFP. T. gondii YFP induced low levels of antibodies to YFP in chickens, suggesting that YFP specific cellular immune response was probably responsible for the protective immunity against E. tenella YFP infection. The measurement of T-cell response and IFN-γ production further confirmed that YFP specific Th1 mediated immune response was induced by T. gondii YFP in immunized chickens. The transgenic T. gondii stimulated significantly higher YFP specific IgG titers in rabbits than in chickens, suggesting greater immunogenicity in a T. gondii susceptible species than in a resistant species. Priming with T. gondii YFP and boosting with the recombinant YFP can induce a strong anti-YFP antibody response in both animal species.
conclusionsOur findings suggest that T. gondii can be used as an effective vaccine vector and future research should focus on exploring avirulent no cyst-forming strains of T. gondii as a live vaccine vector in animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.