ArticleEnvironmental health : a global access science source2011
Identification of sources of lead exposure in French children by lead isotope analysis: a cross-sectional study.
Article in Environmental health : a global access science source, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Lead exposure sources and public health investigations for children with elevated blood lead in England, 2014 to 2022.PloS one · 2024Article
- Identifying Sources of Lead Exposure for Children in the Republic of Georgia, with Lead Isotope Ratios.International journal of environmental research and public health · 2023Article
- Article
- The Use of Pb Isotope Ratios to Determine Environmental Sources of High Blood Pb Concentrations in Children: A Feasibility Study in Georgia.International journal of environmental research and public health · 2022Article
- Potential benefits of joint hypothetical interventions on diet, lead, and cadmium on mortality in US adults.Environmental health : a global access science source · 2022Article
- Reduction in Blood Lead Concentration in Children across the Republic of Georgia following Interventions to Address Widespread Exceedance of Reference Value in 2019.International journal of environmental research and public health · 2021Article
- The Isotopic Signature of Lead Emanations during the Fire at Notre Dame Cathedral in Paris, France.International journal of environmental research and public health · 2021Article
- Source Identification Analysis of Lead in the Blood of Japanese Children by Stable Isotope Analysis.International journal of environmental research and public health · 2020Article
- Sources of Blood Lead Exposure in Rural Bangladesh.Environmental science & technology · 2019Article
- Tracing lead contamination in foods in the city of Kolkata, India.Environmental science and pollution research international · 2016Article
- Associations between metals in residential environmental media and exposure biomarkers over time in infants living near a mining-impacted site.Journal of exposure science & environmental epidemiology · 2016Article
- Screening for Elevated Blood Lead Levels in Children: Assessment of Criteria and a Proposal for New Ones in France.International journal of environmental research and public health · 2015Article
- Persistent organic pollutants (POPs) and metals in primiparous women: a comparison from Canada and Mexico.The Science of the total environment · 2014Article
- Status of metal levels and their potential sources of contamination in Southeast Asian rivers.Environmental science and pollution research international · 2014Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe amount of lead in the environment has decreased significantly in recent years, and so did exposure. However, there is no known safe exposure level and, therefore, the exposure of children to lead, although low, remains a major public health issue. With the lower levels of exposure, it is becoming more difficult to identify lead sources and new approaches may be required for preventive action. This study assessed the usefulness of lead isotope ratios for identifying sources of lead using data from a nationwide sample of French children aged from six months to six years with blood lead levels ≥25 μg/L.
methodsBlood samples were taken from 125 children, representing about 600,000 French children; environmental samples were taken from their homes and personal information was collected. Lead isotope ratios were determined using quadrupole ICP-MS (inductively coupled plasma - mass spectrometry) and the isotopic signatures of potential sources of exposure were matched with those of blood in order to identify the most likely sources.
resultsIn addition to the interpretation of lead concentrations, lead isotope ratios were potentially of use for 57% of children aged from six months to six years with blood lead level ≥ 25 μg/L (7% of overall children in France, about 332,000 children), with at least one potential source of lead and sufficiently well discriminated lead isotope ratios. Lead isotope ratios revealed a single suspected source of exposure for 32% of the subjects and were able to eliminate at least one unlikely source of exposure for 30% of the children.
conclusionsIn France, lead isotope ratios could provide valuable additional information in about a third of routine environmental investigations.
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